The overall 5-year survival for pancreatic cancer has changed little over the past few
decades, and pancreatic cancer is predicted to be the second leading cause of cancer …

Metabolism reprogramming is critical for both cancer progression and effective immune
responses in the tumor microenvironment. Amino acid metabolism in different cells and their …

Tumor-associated macrophages are an abundant cell type in the tumor microenvironment.
These macrophages serve as a promising target for treatment of cancer due to their roles in …

Tumor-associated macrophages (TAMs) promote key processes in tumor progression, like
angiogenesis, immunosuppression, invasion, and metastasis. Increasing studies have also …

Persistent infection with human papillomavirus (HPV) initiates~ 5% of all human cancers,
and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection …

Inflammation is now a well-recognized hallmark of cancer progression. Tumor-associated
macrophages (TAMs) are one of the major inflammatory cells that infiltrate murine and …

Despite the novel diagnostic methods and therapies implemented in oncology, the number
of patients that succumb by the cancer remains high globally. Currently studies point out that …

Increased numbers of tumor-infiltrating macrophages correlate with poor disease outcome in
patients affected by several types of cancer, including breast and prostate carcinomas. The …

T cells in tumors—the so-called tumor infiltrating lymphocytes (TIL) have been studied
intensively over the past years. Compelling evidence point to a clinical relevance for high …

The involvement of the prostaglandin E2 (PGE2) system in cancer progression has long
been recognized. PGE2 functions as an autocrine and paracrine signaling molecule with …