Muscleblind-like (MBNL) proteins are key regulators of precursor and mature mRNA
metabolism in mammals. Based on published and novel data, we explore models of tissue …

Tau microtubule-associated proteins, encoded by the MAPT gene, are mainly expressed in
neurons participating in axonal transport and synaptic plasticity. Six major isoforms …

The alternative splicing of the tau gene, MAPT, generates six protein isoforms in the adult
human central nervous system (CNS). Tau splicing is developmentally regulated and …

Myotonic dystrophy type 1 (DM1) is a multisystem disorder that affects skeletal and smooth
muscle as well as the eye, heart, endocrine system, and central nervous system. The clinical …

For some neurological disorders, disease is primarily RNA mediated due to expression of
non-coding microsatellite expansion RNAs (RNA exp). Toxicity is thought to result from …

Myotonic dystrophies are multisystemic diseases characterized not only by muscle and heart
dysfunction but also by CNS alteration. They are now recognized as brain diseases affecting …

Muscleblind-like (MBNL) proteins are critical RNA processing factors in development. MBNL
activity is disrupted in the neuromuscular disease myotonic dystrophy type 1 (DM1), due to …

Tumor metastasis is the predominant cause of lethality in cancer. We found that
Neobractatin (NBT), a natural compound isolated from Garcinia bracteata, could efficiently …

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an
expansion of CAG repeats in the Huntingtin (HTT) gene. Accumulating evidence suggests …

Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy that affects
multiple systems including the muscle and heart. The mutant CTG expansion at the 3′-UTR …