Simple Summary The purinergic P2X7 receptor (P2X7R) is a cell membrane protein whose
activation has been related to a variety of cellular processes, while its dysregulation has …

Nucleotides are released from all cells through regulated pathways or as a result of plasma
membrane damage or cell death. Outside the cell, nucleotides act as signalling molecules …

The P2X7 receptor (P2X7R) is an ATP-gated membrane ion channel that is expressed by
multiple cell types. Following activation by extracellular ATP, the P2X7R mediates a broad …

Background Neurodegenerative diseases are a common group of neurological disorders
characterized by progressive loss of neuronal structure and function leading to cognitive …

The P2X7 receptor (P2X7R), an ATP-gated ion channel, has emerged as a crucial player in
neuroinflammation and a promising therapeutic target for neurodegenerative disorders. This …

The tumor niche is an environment rich in extracellular ATP (eATP) where purinergic
receptors have essential roles in different cell subtypes, including cancer, immune, and …

Overcoming refractory epilepsy's resistance to the combination of antiepileptic drugs (AED),
mitigating side effects, and preventing sudden unexpected death in epilepsy are critical …

The P2X7 receptor (P2X7R), a non-selective cation channel modulated by adenosine
triphosphate (ATP), localizes to microglia, astrocytes, oligodendrocytes, and neurons in the …

Psychiatric disorders are among the most burdensome disorders worldwide. Though
therapies have evolved over the last decades, treatment resistance still affects many …

Abstract Background The purinergic P2X7 receptor (P2X7R) plays an important role in the
crosstalk between pancreatic stellate cells (PSCs) and cancer cells, thus promoting …