The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …

The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that
plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum (ER) …

Nonalcoholic fatty liver disease is a condition defined by fat accumulation in hepatocytes not
promoted by excessive alcohol consumption. It is highly prevalent and is strongly associated …

Adipose tissue is a complex, multicellular organ that profoundly influences the function of
nearly all other organ systems through its diverse metabolite and adipokine secretome …

Insulin resistance is a complex metabolic disorder that defies explanation by a single
etiological pathway. Accumulation of ectopic lipid metabolites, activation of the unfolded …

Whereas in most cases a fatty liver remains free of inflammation, 10%‐20% of patients who
have fatty liver develop inflammation and fibrosis (nonalcoholic steatohepatitis [NASH]) …

A central function of the endoplasmic reticulum (ER) is to coordinate protein biosynthetic and
secretory activities in the cell. Alterations in ER homeostasis cause accumulation of …

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …

Sensors of pathogens, such as Toll-like receptors (TLRs), detect microbes to activate
transcriptional programs that orchestrate adaptive responses to specific insults. Here we …

A detailed understanding of the processes controlling adipogenesis is instrumental in the
fight against the obesity epidemic. Adipogenesis is controlled by a transcriptional cascade …