Endpoints in NASH clinical trials: are we blind in one eye?

A Lonardo, S Ballestri, A Mantovani, G Targher, F Bril - Metabolites, 2024 - mdpi.com
This narrative review aims to illustrate the notion that nonalcoholic steatohepatitis (NASH),
recently renamed metabolic dysfunction-associated steatohepatitis (MASH), is a systemic …

Recent advances in the management of hepatocellular carcinoma

K Sankar, J Gong, A Osipov, SA Miles… - Clinical and …, 2023 - pmc.ncbi.nlm.nih.gov
Liver cancer remains a challenge of global health, being the 4th leading cause of cancer
death worldwide. Hepatocellular carcinoma (HCC) is the most common type of primary liver …

[HTML][HTML] Red cell distribution width/platelet ratio predicts decompensation of metabolic dysfunction-associated steatotic liver disease-related compensated advanced …

MH Zheng, A Lonardo - World Journal of Gastroenterology, 2025 - pmc.ncbi.nlm.nih.gov
Prognostication of compensated advanced chronic liver disease (cACLD) is of paramount
importance for the physician-and-patient communication and for rational clinical decisions …

The role of noninvasive biomarkers for monitoring cell injury in advanced liver fibrosis

R Riccardo, F Cinque, K Patel… - Expert Review of …, 2025 - Taylor & Francis
Introduction Accurate and reliable diagnosis and monitoring of hepatic fibrosis is
increasingly important given the variable natural history in chronic liver disease (CLD) and …

This Is What Metabolic Dysfunction–Associated Steatotic Liver Disease Looks Like: Potential of a Multiparametric MRI Protocol

AM Fischer, N Lechea, HO Coxson - Seminars in Liver Disease, 2024 - thieme-connect.com
Metabolic dysfunction–associated steatotic liver disease (MASLD) is a prevalent condition
with a broad spectrum defined by liver biopsy. This gold standard method evaluates three …

MASLD: predictive value for liver-related events and extra-hepatic complications

M Jamalinia, A Lonardo - Expert Review of Gastroenterology & …, 2024 - Taylor & Francis
Improved understanding of the natural history of metabolic dysfunction-associated steatotic
liver disease (MASLD) is key to accurate prognostication of disease and ascertainment of …

Prognostic value of ultra-low-pass whole-genome sequencing of circulating tumor DNA in hepatocellular carcinoma under systemic treatment

M Sogbe, I Bilbao, FP Marchese… - Clinical and …, 2023 - pmc.ncbi.nlm.nih.gov
Background/Aims New prognostic markers are needed to identify patients with
hepatocellular carcinoma (HCC) who carry a worse prognosis. Ultra-low-pass whole …

Monitoring disease progression in metabolic dysfunction‐associated steatotic liver disease

N Noureddin, N Copur‐Dahi… - Alimentary Pharmacology …, 2024 - Wiley Online Library
Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most
common cause of chronic liver disease. Its prevalence is increasing with the epidemic of …

A pragmatic management approach for metabolic dysfunction associated steatosis and steatohepatitis

N Shah, AJ Sanyal - Official journal of the American College of …, 2022 - journals.lww.com
Obesity and associated insulin resistance induce a chronic metabo-inflammatory state that
lead to injury and dysfunction of multiple organs resulting in a cluster of noncommunicable …

Role of noninvasive tests in the prognostication of metabolic dysfunction-associated steatotic liver disease

Y Wang, SJ Song, Y Jiang, JCT Lai, GLH Wong… - Clinical and Molecular …, 2024 - e-cmh.org
In managing metabolic dysfunction-associated steatotic liver disease, which affects over
30% of the general population, effective noninvasive biomarkers for assessing disease …