Fibroblast growth factor (FGF)/fibroblast growth factor receptor (FGFR) signaling plays
essential roles in bone development and diseases. Missense mutations in FGFs and FGFRs …

Genetic engineering of model organisms and cultured cells has for decades provided
important insights into the mechanisms underlying cardiovascular development and …

Mouse genetic engineering has revolutionized our understanding of the molecular and
genetic basis of heart development and disease. This technology involves conditional tissue …

Abstract Fibroblast Growth Factor 2 (FGF2), also known as basic fibroblast growth factor, is a
potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back …

Transforming growth factor β1 (TGFβ1) is a multifunctional growth factor involved in wound
healing, tissue fibrosis, and in the pathogenesis of many syndromic diseases (eg, Marfan …

Liver fibrosis, a major cause of end‐stage liver diseases, is closely regulated by multiple
growth factors and cytokines. The correlation of fibroblast growth factor 2 (FGF2) with chronic …

Fibroblast growth factor 2 (FGF-2), ubiquitously expressed in humans and mice, is
functionally involved in cell growth, migration and maturation in vitro and in vivo. Based on …

We previously reported that targeted overexpression of the fibroblast growth factor 2 (FGF2)
high molecular weight (HMW) isoforms in osteoblastic lineage cells in mice resulted in …

FGF2 is an essential growth factor implicated in osteoarthritis (OA), and deletion of full‐
length FGF2 (Fgf2ALLKO) leads to murine OA. However, the FGF2 gene encodes both high …

Fibroblast growth factor 2 (FGF2) consists of multiple protein isoforms (low [LMW] and high
molecular weight [HMW]), which are localized to different cellular compartments, indicating …