Microfluidic devices enable novel means of emulating neurodegenerative disease
pathophysiology in vitro. These organ‐on‐a‐chip systems can potentially reduce animal …

Organs-on-chips (OoCs) have attracted significant attention because they can be designed
to mimic in vivo environments. Beyond constructing a single OoC, recent efforts have tried to …

Motor units are the fundamental elements responsible for muscle movement. They are
formed by lower motor neurons and their muscle targets, synapsed via neuromuscular …

Innervation plays a pivotal role as a driver of tissue and organ development as well as a
means for their functional control and modulation. Therefore, innervation should be carefully …

Microfluidic technology has become a valuable tool to the scientific community, allowing
researchers to study fine cellular mechanisms with higher variable control compared with …

Rett syndrome (RTT), mainly caused by mutations in methyl-CpG binding protein 2
(MeCP2), is one of the most prevalent intellectual disorders without effective therapies. Here …

Embryos devoid of autonomic innervation suffer sudden cardiac death. However, whether
autonomic neurons have a role in heart development is poorly understood. To investigate if …

Human induced pluripotent stem cells (hiPSC) offer an unprecedented opportunity to
generate model systems that facilitate a mechanistic understanding of human disease …

In the last few years microfluidics and microfabrication technique principles have been
extensively exploited for biomedical applications. In this framework, organs-on-a-chip …

The high failure rate in drug development is often attributed to the lack of accurate pre-
clinical models that may lead to false discoveries and inconclusive data when the …