The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology

RJ Grams, WL Santos, IR Scorei, A Abad-García… - Chemical …, 2024 - ACS Publications
Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

[HTML][HTML] Boron chemicals in drug discovery and development: Synthesis and medicinal perspective

BC Das, NK Nandwana, S Das, V Nandwana… - Molecules, 2022 - mdpi.com
A standard goal of medicinal chemists has been to discover efficient and potent drug
candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive …

Recent progress in fabrication and application of BN nanostructures and BN-based nanohybrids

DV Shtansky, AT Matveev, ES Permyakova, DV Leybo… - Nanomaterials, 2022 - mdpi.com
Due to its unique physical, chemical, and mechanical properties, such as a low specific
density, large specific surface area, excellent thermal stability, oxidation resistance, low …

Stem cell–nanomedicine system as a theranostic bio-gadolinium agent for targeted neutron capture cancer therapy

YH Lai, CY Su, HW Cheng, CY Chu, LB Jeng… - Nature …, 2023 - nature.com
The potential clinical application of gadolinium-neutron capture therapy (Gd-NCT) for
glioblastoma multiforme (GBM) treatment has been compromised by the fast clearance and …

Optimizing boron neutron capture therapy (BNCT) to treat cancer: an updated review on the latest developments on boron compounds and strategies

A Monti Hughes, N Hu - Cancers, 2023 - mdpi.com
Simple Summary Boron neutron capture therapy (BNCT) is a tumor-selective particle
radiotherapy. It combines preferential boron accumulation in tumors and neutron irradiation …

The dawn of a new era: tumor-targeting boron agents for neutron capture therapy

T Luo, W Huang, F Chu, T Zhu, B Feng… - Molecular …, 2023 - ACS Publications
Cancer is widely recognized as one of the most devastating diseases, necessitating the
development of intelligent diagnostic techniques, targeted treatments, and early prognosis …

Accelerator-based boron neutron capture therapy facility at the Helsinki University Hospital

L Porra, T Seppälä, L Wendland, H Revitzer… - Acta …, 2022 - Taylor & Francis
Background Boron neutron capture therapy (BNCT) is a unique type of radiation therapy that
enables biological targeting of cancer at the cellular level. BNCT has been used to treat …

Tumor Eradication by Boron Neutron Capture Therapy with 10B‐enriched Hexagonal Boron Nitride Nanoparticles Grafted with Poly(Glycerol)

Y Zhang, HG Kang, H Xu, H Luo, M Suzuki… - Advanced …, 2023 - Wiley Online Library
Boron neutron capture therapy (BNCT) has emerged as a treatment modality with high
precision and efficacy of intractable tumors. At the core of effective tumor BNCT are 10B …

Boron neutron capture therapy: clinical application and research progress

X Cheng, F Li, L Liang - Current Oncology, 2022 - mdpi.com
Boron neutron capture therapy (BNCT) is a binary modality that is used to treat a variety of
malignancies, using neutrons to irradiate boron-10 (10B) nuclei that have entered tumor …

Laser-ablative aqueous synthesis and characterization of elemental boron nanoparticles for biomedical applications

AI Pastukhov, IB Belyaev, JC Bulmahn, IV Zelepukin… - Scientific Reports, 2022 - nature.com
Boron-based nano-formulations look very promising for biomedical applications, including
photo-and boron neutron capture therapies, but the fabrication of non-toxic water-dispersible …