MHC class I molecules and KIRs in human history, health and survival
P Parham - Nature reviews immunology, 2005 - nature.com
MHC class I molecules are ligands for the killer-cell immunoglobulin-like receptors (KIRs),
which are expressed by natural killer cells and T cells. The interactions between these …
which are expressed by natural killer cells and T cells. The interactions between these …
The killer immunoglobulin-like receptor gene cluster: tuning the genome for defense
AA Bashirova, MP Martin, DW McVicar… - Annu. Rev. Genomics …, 2006 - annualreviews.org
Killer immunoglobulin-like receptors (KIRs) are molecules expressed on the surface of
natural killer (NK) cells, which play an important role in innate immunity. KIR recognition of …
natural killer (NK) cells, which play an important role in innate immunity. KIR recognition of …
Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success
SE Hiby, JJ Walker, KM O'shaughnessy… - The Journal of …, 2004 - rupress.org
Preeclampsia is a serious complication of pregnancy in which the fetus receives an
inadequate supply of blood due to failure of trophoblast invasion. There is evidence that the …
inadequate supply of blood due to failure of trophoblast invasion. There is evidence that the …
Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function
M Yawata, N Yawata, M Draghi, AM Little… - The Journal of …, 2006 - rupress.org
Interactions between killer cell immunoglobulin-like receptors (KIRs) and human leukocyte
antigen (HLA) class I ligands regulate the development and response of human natural killer …
antigen (HLA) class I ligands regulate the development and response of human natural killer …
Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes
Inhibitory killer immunoglobulin (Ig)-like receptors (KIRs) recognize HLA-C and-B epitopes
on target cells, thereby regulating natural killer (NK) cell activity. In 178 patients receiving T …
on target cells, thereby regulating natural killer (NK) cell activity. In 178 patients receiving T …
MHC class I–specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response
M Yawata, N Yawata, M Draghi… - Blood, The Journal …, 2008 - ashpublications.org
Variegated expression of 6 inhibitory HLA class I–specific receptors on primary NK cells was
studied using high-dimension flow cytometry in 58 humans to understand the structure and …
studied using high-dimension flow cytometry in 58 humans to understand the structure and …
Different Patterns of Evolution in the Centromeric and Telomeric Regions of Group A and B Haplotypes of the Human Killer Cell Ig-Like Receptor Locus
CW Pyo, LA Guethlein, Q Vu, R Wang, L Abi-Rached… - PloS one, 2010 - journals.plos.org
The fast evolving human KIR gene family encodes variable lymphocyte receptors specific for
polymorphic HLA class I determinants. Nucleotide sequences for 24 representative human …
polymorphic HLA class I determinants. Nucleotide sequences for 24 representative human …
KIR and disease: a model system or system of models?
SI Khakoo, M Carrington - Immunological reviews, 2006 - Wiley Online Library
The discovery of an unexpected level of diversity among the killer cell immunoglobulin‐like
receptors has led to a search for their role in human disease. Due to their polymorphism and …
receptors has led to a search for their role in human disease. Due to their polymorphism and …
Natural killer cells and cancer: regulation by the killer cell Ig-like receptors (KIR)
AK Purdy, KS Campbell - Cancer biology & therapy, 2009 - Taylor & Francis
Natural killer (NK) cells are innate immune effector cells that make up~ 10-15% of the
peripheral blood lymphocytes in humans and are primarily involved in immunosurveillance …
peripheral blood lymphocytes in humans and are primarily involved in immunosurveillance …
The protein made from a common allele of KIR3DL1 (3DL1* 004) is poorly expressed at cell surfaces due to substitution at positions 86 in Ig domain 0 and 182 in Ig …
MJ Pando, CM Gardiner, M Gleimer… - The Journal of …, 2003 - journals.aai.org
KIR3DL1 is an inhibitory HLA-B receptor of human NK and T cells that exhibits genetic and
phenotypic polymorphism. KIR3DL1* 004, a common allotype, cannot be detected on the …
phenotypic polymorphism. KIR3DL1* 004, a common allotype, cannot be detected on the …