Nicotine is a highly addictive drug found in tobacco that drives its continued use despite the
harmful consequences. The initiation of nicotine abuse involves the mesolimbic dopamine …

Abstract Purpose of Review With the advent of the genome-wide association study (GWAS),
our understanding of the genetics of addiction has made significant strides forward. Here …

Background Smoking is a strong environmental factor leading to adverse outcomes in
Crohn's disease, but a more benign course in ulcerative colitis. Several single nucleotide …

Background and Objectives Genetic studies have revealed a significant association
between variants in nicotinic acetylcholine receptor (CHRN) genes and smoking cessation …

Background Chronic obstructive pulmonary disease (COPD) is a multifactorial disorder
which is affected by external and internal risk factors. People with no external risk factors …

Purpose Most smokers attempt to quit smoking, but few are successful. Data regarding the
reasons for this relapse and the course of the relapse process may be helpful for …

Background The identification of variants in the nicotinic acetylcholine receptor (nAChR)
subunit genes associated with smoking phenotypes are increasingly important for …

Polymorphisms in the CHRNA5-CHRNA3-CHRNB4 gene cluster (Chr15q25) have been
robustly associated with nicotine dependence, including genome-wide studies, as well as …

Tobacco is legally permitted for adults, easily available, and the prevalence of smoking is
high. Tobacco use is the largest preventable risk factor for human disease. To reduce …

Recent studies have confirmed the wide consumption of tobacco and alcohol in our society
and the strong addiction generated by these substances, which is responsible for high …