[HTML][HTML] Actinobacteria in natural products research: Progress and prospects
Actinobacteria are well-recognised biosynthetic factories that produce an extensive
spectrum of secondary metabolites. Recent genomic insights seem to impact the exploitation …
spectrum of secondary metabolites. Recent genomic insights seem to impact the exploitation …
Exploring structural diversity of microbe secondary metabolites using OSMAC strategy: A literature review
R Pan, X Bai, J Chen, H Zhang, H Wang - Frontiers in Microbiology, 2019 - frontiersin.org
Microbial secondary metabolites (MSMs) have played and continue to play a highly
significant role in the drug discovery and development process. Genetically, MSM chemical …
significant role in the drug discovery and development process. Genetically, MSM chemical …
Activating cryptic biosynthetic gene cluster through a CRISPR–Cas12a-mediated direct cloning approach
M Liang, L Liu, F Xu, X Zeng, R Wang… - Nucleic Acids …, 2022 - academic.oup.com
Direct cloning of biosynthetic gene clusters (BGCs) from microbial genomes facilitates
natural product-based drug discovery. Here, by combining Cas12a and the advanced …
natural product-based drug discovery. Here, by combining Cas12a and the advanced …
NP analyst: an open online platform for compound activity mapping
Few tools exist in natural products discovery to integrate biological screening and
untargeted mass spectrometry data at the library scale. Previously, we reported Compound …
untargeted mass spectrometry data at the library scale. Previously, we reported Compound …
The secondary metabolites of rare actinomycetes: chemistry and bioactivity
T Ding, LJ Yang, WD Zhang, YH Shen - RSC advances, 2019 - pubs.rsc.org
Actinomycetes are outstanding and fascinating sources of potent bioactive compounds,
particularly antibiotics. In recent years, rare actinomycetes have had an increasingly …
particularly antibiotics. In recent years, rare actinomycetes have had an increasingly …
Genomic and spectroscopic signature-based discovery of natural macrolactams
The logical and effective discovery of macrolactams, structurally unique natural molecules
with diverse biological activities, has been limited by a lack of targeted search methods …
with diverse biological activities, has been limited by a lack of targeted search methods …
Discovery of novel secondary metabolites encoded in actinomycete genomes through coculture
Actinomycetes are a rich source of bioactive natural products important for novel drug leads.
Recent genome mining approaches have revealed an enormous number of secondary …
Recent genome mining approaches have revealed an enormous number of secondary …
Utilizing cross-species co-cultures for discovery of novel natural products
Highlights•Cross-species co-cultures can be used to activate cryptic genes' expression for
biosynthesis of novel natural products.•A variety of co-cultivation methods have been …
biosynthesis of novel natural products.•A variety of co-cultivation methods have been …
Genome mining for macrolactam-encoding gene clusters allowed for the network-guided isolation of β-amino acid-containing cyclic derivatives and heterologous …
E Seibel, S Um, M Dayras, KH Bodawatta… - Communications …, 2023 - nature.com
Abstract β-Amino acid-containing macrolactams represent a structurally diverse group of
bioactive natural products derived from polyketides; however we are currently lacking a …
bioactive natural products derived from polyketides; however we are currently lacking a …
Activation of silent biosynthetic pathways and discovery of novel secondary metabolites in actinomycetes by co-culture with mycolic acid-containing bacteria
Bacterial secondary metabolites (SM) are rich sources of drug leads, and in particular,
numerous metabolites have been isolated from actinomycetes. It was revealed by recent …
numerous metabolites have been isolated from actinomycetes. It was revealed by recent …