Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …

Recent studies have highlighted that splicing patterns are frequently altered in cancer and
that mutations in genes encoding spliceosomal proteins, as well as mutations affecting the …

Cellular functions depend on numerous protein-coding and noncoding RNAs and the RNA-
binding proteins associated with them, which form ribonucleoprotein complexes (RNPs) …

Influenza A virus, being responsible for seasonal epidemics and reoccurring pandemics,
represents a worldwide threat to public health. High mutation rates facilitate the generation …

Several bacterial fermentation products and their synthetic derivatives display antitumour
activities and bind tightly to components of the spliceosome, which is the complex molecular …

The tight control of gene expression at the level of both transcription and post-transcriptional
RNA processing is essential for mammalian development. We here investigate the role of …

Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …

Androgen receptor (AR) splice variants (AR-Vs) have been implicated in the development
and progression of metastatic prostate cancer. AR-Vs are truncated isoforms of the AR, a …

Alternative splicing is the major source of proteome diversity in humans and thus is highly
relevant to disease and therapy. For example, recent work suggests that the long-sought …

Objectives Wnt pathway upregulation contributes to knee osteoarthritis (OA) through
osteoblast differentiation, increased catabolic enzymes, and inflammation. The small …