Forty years since the initial discovery of neurogenesis in the postnatal rat hippocampus,
investigators have now firmly established that active neurogenesis from neural progenitors …

The Control of Neuron Number Page 1 Select Phenotype Database Site search Search
Publications Home Publications List of Contents Quantitative Neurogenetics & QTL Mapping …

Neurogenesis and gliogenesis continue in discrete regions of the adult mammalian brain. A
fundamental question remains whether cell genesis occurs from distinct lineage-restricted …

Each cell lineage specified in the preimplantation mammalian embryo depends on intrinsic
factors for its development, but there is also mutual interdependence between them. OCT4 is …

Delivery of therapeutic proteins into tissues and across the blood-brain barrier is severely
limited by the size and biochemical properties of the proteins. Here it is shown that …

Growth and repair of skeletal muscle are normally mediated by the satellite cells that
surround muscle fibers. In regenerating muscle, however, the number of myogenic …

The subventricular zone of the postnatal forebrain produces mainly glia, although it supports
limited neurogenesis. To determine whether the subventricular zone is positionally …

A general strategy for selecting insertion mutations in mice has been devised. Constructs
lacking a promoter and including a beta-galactosidase gene, or a reporter gene encoding a …

The process wherein dividing cells exhaust proliferative capacity and enter into replicative
senescence has become a prominent model for cellular aging in vitro. Despite decades of …

The transplantation of cultured myoblasts into mature skeletal muscle is the basis for a new
therapeutic approach to muscle and non-muscle diseases: myoblast-mediated gene …