In total, twenty elements appear to be essential for the correct functioning of the human
body, half of which are metals and half are non-metals. Among those metals that are …

Obesity is associated with the development of various complications, including diabetes,
atherosclerosis, and an increased risk for infections, driven by dysfunctional innate immune …

Highlights•Siderophores/metallophores mediate metal acquisition and host-microbe
interactions.•Genome mining aids metallophore discovery, dereplication, and …

Inorganic polyphosphate (polyP) is primarily synthesized by Polyphosphate Kinase-1 (PPK-
1) and regulates numerous cellular processes, including energy metabolism, stress …

Living systems are built from a small subset of the atomic elements, including the bulk
macronutrients (C, H, N, O, P, S) and ions (Mg, K, Na, Ca) together with a small but variable …

A number of bacteria are known to produce isonitrile-containing peptides (INPs) that
facilitate metal transport and are important for cell survival; however, considerable structural …

Aspergillus fumigatus has been designated by the World Health Organization as a critical
priority fungal pathogen. Some commercially available diagnostics for many forms of …

Bacterial pathogens and their hosts engage in intense competition for critical nutrients
during infection, including metals such as iron, copper, and zinc. Some metals are limited by …

The human pathogen Mycobacterium tuberculosis requires a P1B-ATPase metal exporter,
CtpC (Rv3270), for resistance to zinc poisoning. Here, we show that zinc resistance also …

Many bacteria secrete metallophores, low-molecular-weight organic compounds that bind
ions with high selectivity and affinity, in order to access essential metals from the …