Multiple mechanisms are involved in driving the efficacy of drug delivery. Drug particle size
is one of the challenges as particles need to be delivered from the external environment, into …

Cisplatin is widely used for the treatment of a number of solid malignant tumors. However,
ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for …

Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous
system and in sensory structures including olfactory and auditory systems. Many studies …

Epidemiologic studies of hearing loss in adults have demonstrated that the odds of hearing
loss are substantially lower in black than in white individuals. The basis of this association is …

Hearing loss is the most common neurosensory impairment worldwide. While conductive
hearing loss can be managed by surgery, the management of sensorineural hearing loss …

Spiral ganglion cell (SGC) degeneration following hair cell loss can be prevented by
administration of exogenous neurotrophic factors. Many of these neurotrophic factors, in …

For many years, drug delivery to the inner ear has been a challenge to physicians in the
treatment of inner ear disorders. In the past decade, the field of inner ear drug delivery has …

Treating pathologies of the inner ear is a major challenge. To date, a wide range of
procedures exists for administering therapeutic agents to the inner ear, with varying degrees …

Cisplatin is a chemotherapeutic agent that causes the irreversible death of auditory sensory
cells, leading to hearing loss. Local administration of cytoprotective drugs is a potentially …

The aim of this work is the development of highly protective agents to be administered
locally within the middle ear to avoid cisplatin-induced ototoxicity, which affects to 100% of …