This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

In arbitrary dimension, in the discrete setting of finite-differences we prove a Carleman
estimate for a semi-discrete parabolic operator, in which the large parameter is connected to …

Cardiovascular diseases (CVD)(such as occlusion of the coronary arteries, hypertensive
heart diseases and strokes) are diseases that generate thousands of patients with a high …

Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In
most cases, multiple drugs are used, as resistance to single agents occurs almost …

Free radicals and other reactive species (RS) are thought to play an important role in many
human diseases. Establishing their precise role requires the ability to measure them and the …

In tumor cell lines, multidrug resistance is often associated with an ATP-dependent decrease
in cellular drug accumulation which is attributed to the overexpression of certain ATP …

In liver and intestine, transporters play a critical role in maintaining the enterohepatic
circulation and bile acid homeostasis. Over the past two decades, there has been significant …

The acquisition of multidrug resistance is a serious impediment to improved healthcare.
Multidrug resistance is most frequently due to active transporters that pump a broad …

Bilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver
into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood …

Reduced glutathione (GSH) is the most abundant non-protein endogenous thiol. It is a
ubiquitous molecule produced in most organs, but its synthesis is predominantly in the liver …