In response to stress, the brain activates several neuropeptide-secreting systems. This
eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed …

Cortical growth and remodeling continues from birth through youth and adolescence to
stable adult levels changing slowly into senescence. There are critical periods of cortical …

Background Hippocampal volume loss is a hallmark of clinical depression. Chronic stress
produces volume loss in the hippocampus in humans and atrophy of CA3 pyramidal cells …

Creating a healthy, social classroom environment. This book explains how the brain, as a
social organism, learns best throughout the lifespan, from our early schooling through late …

Understanding the physiopathology of affective disorders and their treatment relies on the
availability of experimental models that accurately mimic aspects of the disease. Here we …

Context Our genome adapts to environmental influences, in part through epigenetic
mechanisms, including DNA methylation. Variations in the quality of the early environment …

Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside
within distinct regions of the brain. This phenomenon was first described over 50 years ago …

The discovery that the adult mammalian brain creates new neurons from pools of stemlike
cells was a breakthrough in neuroscience. Interestingly, this particular new form of structural …

Exposure to an enriched environment and physical activity, such as voluntary running,
increases neurogenesis of granule cells in the dentate gyrus of adult mice. These stimuli are …

The dentate gyrus of the hippocampus continues to produce new neurons throughout
adulthood. Adult neurogenesis has been linked to hippocampal function, including learning …