Impaired bone healing occurs in 5–10% of cases following injury, leading to a significant
economic and clinical impact. While an inflammatory response upon injury is necessary to …

Orthopedic and dental implants have been used successfully for decades to replace or
repair missing or damaged bones, joints, and teeth, thereby restoring patient function …

Synthetic matrices emulating the physicochemical properties of tissue-specific ECMs are
being developed at a rapid pace to regulate stem cell fate. Biomaterials containing calcium …

Critical size bone defects raise great demands for efficient bone substitutes. Mimicking the
hierarchical porous architecture and specific biological cues of natural bone has been …

Affinity-based release systems use transient interactions to sustain and control the release of
a therapeutic from a polymeric matrix. The most common affinity-based systems use heparin …

Implant-associated infections are among the most serious post-surgical complications of
medical device implants, including prosthetic joints (eg, hip, knee and shoulder) and fracture …

The extracellular matrix (ECM) is the non-cellular component of tissue that provides physical
scaffolding to cells. Emerging studies have shown that beyond structural support, the ECM …

Proteins tend to lose their biological activity due to their fragile structural conformation during
formulation, storage, and delivery. Thus, the inability to stabilize proteins in controlled …

Introduction: Large bone defects (LBD) caused by trauma, infection, and tumor resection
remain a significant clinical challenge. Although therapeutic agents such as bone …

There is an increasing need to control the type, quantity, and timing of growth factors
released during tissue healing. Sophisticated delivery systems offering the ability to deliver …