The pan-immune system of bacteria: antiviral defence as a community resource
A Bernheim, R Sorek - Nature reviews microbiology, 2020 - nature.com
Viruses and their hosts are engaged in a constant arms race leading to the evolution of
antiviral defence mechanisms. Recent studies have revealed that the immune arsenal of …
antiviral defence mechanisms. Recent studies have revealed that the immune arsenal of …
Understanding bacteriophage tail fiber interaction with host surface receptor: the key “blueprint” for reprogramming phage host range
Bacteriophages (phages), as natural antibacterial agents, are being rediscovered because
of the growing threat of multi-and pan-drug-resistant bacterial pathogens globally. However …
of the growing threat of multi-and pan-drug-resistant bacterial pathogens globally. However …
Diverse enzymatic activities mediate antiviral immunity in prokaryotes
Bacteria and archaea are frequently attacked by viruses and other mobile genetic elements
and rely on dedicated antiviral defense systems, such as restriction endonucleases and …
and rely on dedicated antiviral defense systems, such as restriction endonucleases and …
Broad-spectrum CRISPR-Cas13a enables efficient phage genome editing
CRISPR-Cas13 proteins are RNA-guided RNA nucleases that defend against incoming
RNA and DNA phages by binding to complementary target phage transcripts followed by …
RNA and DNA phages by binding to complementary target phage transcripts followed by …
[HTML][HTML] Dynamic modulation of the gut microbiota and metabolome by bacteriophages in a mouse model
The human gut microbiome is comprised of densely colonizing microorganisms including
bacteriophages, which are in dynamic interaction with each other and the mammalian host …
bacteriophages, which are in dynamic interaction with each other and the mammalian host …
Thousands of previously unknown phages discovered in whole-community human gut metagenomes
Background Double-stranded DNA bacteriophages (dsDNA phages) play pivotal roles in
structuring human gut microbiomes; yet, the gut virome is far from being fully characterized …
structuring human gut microbiomes; yet, the gut virome is far from being fully characterized …
Genomically recoded organisms expand biological functions
We describe the construction and characterization of a genomically recoded organism
(GRO). We replaced all known UAG stop codons in Escherichia coli MG1655 with …
(GRO). We replaced all known UAG stop codons in Escherichia coli MG1655 with …
Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire
EV Koonin, KS Makarova, YI Wolf… - Nature Reviews …, 2020 - nature.com
All cellular life forms are afflicted by diverse genetic parasites, including viruses and other
types of mobile genetic elements (MGEs), and have evolved multiple, diverse defence …
types of mobile genetic elements (MGEs), and have evolved multiple, diverse defence …
Bionanoparticles in cancer imaging, diagnosis, and treatment
Biological molecules such as DNA, proteins, and lipids can be assembled into naturally
existing nanoparticles, such as bacterial viruses (also called bacteriophages or phages) …
existing nanoparticles, such as bacterial viruses (also called bacteriophages or phages) …
Galaxy and Apollo as a biologist-friendly interface for high-quality cooperative phage genome annotation
In the modern genomic era, scientists without extensive bioinformatic training need to apply
high-power computational analyses to critical tasks like phage genome annotation. At the …
high-power computational analyses to critical tasks like phage genome annotation. At the …