Owing to the market competitiveness and urgent societal need, an optimum speed of drug
discovery is an important criterion for successful implementation. Despite the rapid ascent of …

Because of a preconceived notion that eliminating reactive metabolite (RM) formation with
new drug candidates could mitigate the risk of idiosyncratic drug toxicity, the potential for RM …

A greener, cost efficient and simple method is described to prepare copper nanoparticles
(NPs) immobilized on the magnetic chitosan (one of the more versatile polysaccharides) …

Angiotensin II type 1 receptor antagonists (ARBs) have become an important drug class in
the treatment of hypertension and heart failure and the protection from diabetic nephropathy …

Thiophene is a five-membered, sulfur-containing heteroaromatic ring commonly used as a
building block in drugs. It is considered to be a structural alert, as its metabolism can lead to …

The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …

Overcoming multidrug resistance represents a major challenge for cancer treatment. In the
search for new chemotherapeutics to treat malignant diseases, drug repurposing gained a …

The installation of azoles via C–H/N–H cross-coupling is significantly underdeveloped,
particularly in benzylic C–H azolation due to the requirement for external chemical oxidants …

Human cytochrome P450 2C9 (CYP2C9) accounts for∼ 20% of total hepatic CYP content
and metabolizes∼ 15% clinically used drugs including S-warfarin, tolbutamide, phenytoin …

Pharmacologically active metabolites can contribute significantly to the overall therapeutic
and adverse effects of drugs. Therefore, to fully understand the mechanism of action of …