Endoplasmic reticulum stress: an arising target for metal-based anticancer agents

AP King, JJ Wilson - Chemical Society Reviews, 2020 - pubs.rsc.org
The endoplasmic reticulum (ER) has recently emerged as a promising target for anticancer
agents. Cytotoxic compounds that target the ER often exhibit selectivity for cancer cells over …

Cyclometalated iridium (III) luminescent complexes in therapy and phototherapy

A Zamora, G Vigueras, V Rodríguez… - Coordination Chemistry …, 2018 - Elsevier
Octahedral Ir (III) complexes bearing cyclometalated ligands exhibit a great stability in
biological media and are excellent therapeutical and phototherapeutical candidates for …

Organelle-targeting metal complexes: From molecular design to bio-applications

K Qiu, Y Chen, TW Rees, L Ji, H Chao - Coordination Chemistry Reviews, 2019 - Elsevier
Cellular organelles, such the cytomembrane, lysosome, mitochondrion, Golgi apparatus, the
endoplasmic reticulum, and nucleus, play important roles in the normal function of cells …

Tuning the Organelle-Specific Imaging and Photodynamic Therapeutic Efficacy of Theranostic Mono-and Trinuclear Organometallic Iridium (III) Complexes

B Das, S Gupta, A Mondal, KJ Kalita… - Journal of Medicinal …, 2023 - ACS Publications
The organelle-specific localization of mononuclear and trinuclear iridium (III) complexes and
their photodynamic behavior within the cells are described herein, emphasizing their …

Recent advances in endoplasmic reticulum targeting metal complexes

C Huang, T Li, J Liang, H Huang, P Zhang… - Coordination Chemistry …, 2020 - Elsevier
Over the last few years, significant attention has been paid to develop metal complexes for
different cellular organelle specific imaging agents and to achieve organelle targeting …

[HTML][HTML] A rhenium isonitrile complex induces unfolded protein response-mediated apoptosis in cancer cells

AP King, SC Marker, RV Swanda… - … (Weinheim an der …, 2019 - ncbi.nlm.nih.gov
Complexes of the element Re have recently been shown to possess promising anticancer
activity via mechanisms of action that are distinct from the conventional metal-based drug …

Exploring the in vivo and in vitro anticancer activity of rhenium isonitrile complexes

SC Marker, AP King, S Granja, B Vaughn… - Inorganic …, 2020 - ACS Publications
The established platinum-based drugs form covalent DNA adducts to elicit their cytotoxic
response. Although they are widely employed, these agents cause toxic side-effects and are …

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

LCC Lee, KKW Lo - Chemical Reviews, 2024 - ACS Publications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

Thiabendazole-based Rh (III) and Ir (III) biscyclometallated complexes with mitochondria-targeted anticancer activity and metal-sensitive photodynamic activity

C Pérez-Arnaiz, MI Acuña, N Busto, I Echevarría… - European Journal of …, 2018 - Elsevier
Two pairs of Rh (III) and Ir (III) biscyclometallated complexes with thiabendazole (L 1),
named [Ir-a] Cl and [Rh-a] Cl, and N-benzyl-thiabendazole (L 2), named [Ir-b] Cl and [Rh-b] …

A Cyclometalated IrIII Complex as a Lysosome‐Targeted Photodynamic Therapeutic Agent for Integrated Imaging and Therapy in Cancer Cells

KV Sudheesh, PS Jayaram, A Samanta… - … A European Journal, 2018 - Wiley Online Library
Organelle‐targeted photosensitizers (PSs) having luminescence properties are potential
theranostic agents for simultaneous luminescence imaging and photodynamic therapy …