Over the past 10 years, the field of immunometabolism made great strides to unveil the
crucial role of intracellular metabolism in regulating immune cell function. Emerging insights …

The human microbiome influences the efficacy and safety of a wide variety of commonly
prescribed drugs. Designing precision medicine approaches that incorporate microbial …

Microbes do not live in isolation but in microbial communities. The relevance of microbial
communities is increasing due to growing awareness of their influence on a huge number of …

The aim of this tutorial is to introduce the fundamental concepts of physiologically based
pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their …

Comprehensive molecular‐level models of human metabolism have been generated on a
cellular level. However, models of whole‐body metabolism have not been established as …

Comprehensive whole-body models (WBMs) accounting for organ-specific dynamics have
been developed to simulate adult metabolism, but such models do not exist for infants. Here …

Metabolic networks are regulated to ensure the dynamic adaptation of biochemical reaction
fluxes to maintain cell homeostasis and optimal metabolic fitness in response to …

Bile salt export pump (BSEP) inhibition has emerged as an important mechanism that may
contribute to the initiation of human drug‐induced liver injury (DILI). Proactive evaluation …

Cancer cells reprogram metabolism to support rapid proliferation and survival. Energy
metabolism is particularly important for growth and genes encoding enzymes involved in …

Plant metabolism is characterized by a unique complexity on the cellular, tissue, and organ
levels. On a whole-plant scale, changing source and sink relations accompanying plant …