The perspectives of regenerative medicine are still severely hampered by the host response
to biomaterial implantation, despite the robustness of technologies that hold the promise to …

The immune system plays a central role in tissue repair and regeneration. Indeed, the
immune response to tissue injury is crucial in determining the speed and the outcome of the …

The worldwide incidence of bone disorders and conditions has trended steeply upward and
is expected to double by 2020, especially in populations where aging is coupled with …

Arachidonic acid (ARA, 20: 4 n-6) is an n-6 polyunsaturated 20-carbon fatty acid formed by
the biosynthesis from linoleic acid (LA, 18: 2 n-6). This review considers the essential role …

Epilepsy is a group of chronic neurological disorders that have diverse etiologies but are
commonly characterized by spontaneous seizures and behavioral comorbidities. Although …

The intimate connection, both physical and biochemical, between blood vessels and bone
cells has long been recognized. Genetic, biochemical, and pharmacological studies have …

The ability to regenerate damaged tissues is a common characteristic of multicellular
organisms. We report a role for apoptotic cell death in promoting wound healing and tissue …

Proinflammatory cytokines are infamous for their catabolic effects on tissues and joints in
both inflammatory diseases and following the implantation of biomedical devices. However …

Prostaglandins (PGs) are multifunctional regulators of bone metabolism that stimulate both
bone resorption and formation. PGs have been implicated in bone resorption associated …

Bones serve several mechanical functions, including acoustic amplification in the middle
ear, shielding vital organs from trauma, and serving as levers for muscles to contract against …