Pseudouridine (Ψ) is the most abundant of> 150 nucleoside modifications in RNA. Although
Ψ was discovered as the first modified nucleoside more than half a century ago, neither the …

Prolonged exposure to ultraviolet radiation on human skin can lead to mutations in DNA,
photoaging, suppression of the immune system, and other damage up to skin cancer …

Modified mRNA (modRNA) is a new technology in the field of somatic gene transfer that has
been used for the delivery of genes into different tissues, including the heart. Our group and …

Ultraviolet (UV) light is absorbed by nucleic acids, proteins or other endogenous
chromophores, such as porphyrins, flavins and melanin, triggering biological processes in …

Therapeutic messenger RNAs (mRNAs) have emerged as powerful tools in the treatment of
complex diseases, especially for conditions that lack efficacious treatment. The successful …

With the success of COVID-19 vaccines, newly created mRNA vaccines against other
infectious diseases are beginning to emerge. Here, we review the structural elements …

Use of RNA is an increasingly popular method to transiently deliver genetic information for
cell manipulation in basic research and clinical therapy. In these settings, viral and nonviral …

Keratinocytes provide the first line of defense of the human body against carcinogenic
ultraviolet (UV) radiation. Acute and chronic UVB-mediated cellular responses were widely …

The mRNA epitranscriptome imparts diversity to gene expression by installing chemical
modifications. Advances in detection methods have identified chemical modifications in …

Ultraviolet B radiation (UVB) is an environmental complete carcinogen, which induces and
promotes keratinocyte carcinomas, the most common human malignancies. UVB induces …