HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum
The HSPA5 gene encodes the binding immunoglobulin protein (BiP), an Hsp70 family
chaperone localized in the ER lumen. As a highly conserved molecular chaperone, BiP …
chaperone localized in the ER lumen. As a highly conserved molecular chaperone, BiP …
Regulation of calcium homeostasis and flux between the endoplasmic reticulum and the cytosol
L Daverkausen-Fischer, F Pröls - Journal of Biological Chemistry, 2022 - ASBMB
The concentration of Ca 2+ in the endoplasmic reticulum (ER) is critically important for
maintaining its oxidizing environment as well as for maintaining luminal ATP levels required …
maintaining its oxidizing environment as well as for maintaining luminal ATP levels required …
Metabolic implications of organelle–mitochondria communication
I Gordaliza‐Alaguero, C Cantó, A Zorzano - EMBO reports, 2019 - embopress.org
Cellular organelles are not static but show dynamism—a property that is likely relevant for
their function. In addition, they interact with other organelles in a highly dynamic manner. In …
their function. In addition, they interact with other organelles in a highly dynamic manner. In …
Protein folding in the endoplasmic reticulum
I Braakman, DN Hebert - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
In this article, we will cover the folding of proteins in the lumen of the endoplasmic reticulum
(ER), including the role of three types of covalent modifications: signal peptide removal, N …
(ER), including the role of three types of covalent modifications: signal peptide removal, N …
Calcium signaling and endoplasmic reticulum stress
J Groenendyk, LB Agellon, M Michalak - International review of cell and …, 2021 - Elsevier
Cellular homeostasis is essential for healthy functioning of cells and tissues as well as
proper organ development and maintenance. A disruption in cellular homeostasis triggers …
proper organ development and maintenance. A disruption in cellular homeostasis triggers …
An update on Sec61 channel functions, mechanisms, and related diseases
The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the
protein translocon, which facilitates membrane integration or translocation of almost every …
protein translocon, which facilitates membrane integration or translocation of almost every …
BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functions
BiP (immunoglobulin heavy-chain binding p rotein) is the endoplasmic reticulum (ER)
orthologue of the Hsp70 family of molecular chaperones and is intricately involved in most …
orthologue of the Hsp70 family of molecular chaperones and is intricately involved in most …
Let's talk about Secs: Sec61, Sec62 and Sec63 in signal transduction, oncology and personalized medicine
M Linxweiler, B Schick, R Zimmermann - Signal transduction and …, 2017 - nature.com
The heterotrimeric Sec61 complex and the dimeric Sec62/Sec63 complex are located in the
membrane of the human endoplasmic reticulum (ER) and play a central role in translocation …
membrane of the human endoplasmic reticulum (ER) and play a central role in translocation …
[HTML][HTML] Co-translational targeting and translocation of proteins to the endoplasmic reticulum
Co-translational protein targeting to the endoplasmic reticulum (ER), represents an
evolutionary-conserved mechanism to target proteins into the secretory pathway. In this …
evolutionary-conserved mechanism to target proteins into the secretory pathway. In this …
The Sec translocon mediated protein transport in prokaryotes and eukaryotes
K Denks, A Vogt, I Sachelaru, NA Petriman… - Molecular membrane …, 2014 - Taylor & Francis
Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …