Traditional views of cellular metabolism imply that it is passively adapted to meet the
demands of the cell. It is becoming increasingly clear, however, that metabolites do more …

Posttranslational modifications (PTMs) refer to amino acid side chain modification in some
proteins after their biosynthesis. There are more than 400 different types of PTMs affecting …

Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …

Abstract Divergent N6-methyladenosine (m6A) modifications are dynamic and reversible
posttranscriptional RNA modifications that are mediated by m6A regulators or m6A RNA …

The precise temporal and spatial coordination of histone lysine methylation dynamics across
the epigenome regulates virtually all DNA-templated processes. A large number of histone …

Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Post-translational modification (PTM) in histone proteins is a covalent modification which
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …

During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have
been the primary model organisms used for the study of various biological phenomena …

The alkylating agent temozolomide (TMZ) together with maximal safe bulk resection and
focal radiotherapy comprises the standard treatment for glioblastoma (GB), a particularly …

Increased protein synthesis plays an etiologic role in diverse cancers. Here, we demonstrate
that METTL13 (methyltransferase-like 13) dimethylation of eEF1A (eukaryotic elongation …