Cytokine networks in the pathogenesis of rheumatoid arthritis
N Kondo, T Kuroda, D Kobayashi - International journal of molecular …, 2021 - mdpi.com
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic
inflammation causing progressive joint damage that can lead to lifelong disability. The …
inflammation causing progressive joint damage that can lead to lifelong disability. The …
The TNF family of ligands and receptors: communication modules in the immune system and beyond
C Dostert, M Grusdat, E Letellier… - Physiological …, 2019 - journals.physiology.org
The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …
Post-stroke inflammation—target or tool for therapy?
KL Lambertsen, B Finsen, BH Clausen - Acta neuropathologica, 2019 - Springer
Inflammation is currently considered a prime target for the development of new stroke
therapies. In the acute phase of ischemic stroke, microglia are activated and then circulating …
therapies. In the acute phase of ischemic stroke, microglia are activated and then circulating …
TNF biology, pathogenic mechanisms and emerging therapeutic strategies
GD Kalliolias, LB Ivashkiv - Nature reviews rheumatology, 2016 - nature.com
TNF is a pleiotropic cytokine with important functions in homeostasis and disease
pathogenesis. Recent discoveries have provided insights into TNF biology that introduce …
pathogenesis. Recent discoveries have provided insights into TNF biology that introduce …
Role of TNF–TNF receptor 2 signal in regulatory T cells and its therapeutic implications
Tumor necrosis factor α (TNFα) is a pleiotropic cytokine which signals through TNF receptor
1 (TNFR1) and TNF receptor 2 (TNFR2). Emerging evidence has demonstrated that TNFR1 …
1 (TNFR1) and TNF receptor 2 (TNFR2). Emerging evidence has demonstrated that TNFR1 …
Drugs for autoimmune inflammatory diseases: from small molecule compounds to anti-TNF biologics
Although initially described as an anti-tumor mediator, tumor necrosis factor-alpha (TNF) is
generally considered as the master pro-inflammatory cytokine. It plays a crucial role in the …
generally considered as the master pro-inflammatory cytokine. It plays a crucial role in the …
Anti-TNF therapy: past, present and future
C Monaco, J Nanchahal, P Taylor… - International …, 2015 - academic.oup.com
While for a century therapeutics has been dominated by small molecules, ie organic
chemicals of~ 400Da absorbable via the gut, this is no longer the case. There are now a …
chemicals of~ 400Da absorbable via the gut, this is no longer the case. There are now a …
[HTML][HTML] TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects
L Probert - Neuroscience, 2015 - Elsevier
Tumor necrosis factor (TNF) is the prototypic pro-inflammatory cytokine. It is central to host
defense and inflammatory responses but under certain circumstances also triggers cell …
defense and inflammatory responses but under certain circumstances also triggers cell …
Molecular mechanisms of action of anti-TNF-α agents–Comparison among therapeutic TNF-α antagonists
H Mitoma, T Horiuchi, H Tsukamoto, N Ueda - Cytokine, 2018 - Elsevier
Tumor necrosis factor (TNF)-α is a potent pro-inflammatory and pathological cytokines in
inflammatory diseases such as rheumatoid arthritis and inflammatory bowel diseases. Anti …
inflammatory diseases such as rheumatoid arthritis and inflammatory bowel diseases. Anti …
Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases
M Croft, RM Siegel - Nature Reviews Rheumatology, 2017 - nature.com
TNF blockers are highly efficacious at dampening inflammation and reducing symptoms in
rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and ankylosing …
rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and ankylosing …