Type 2 diabetes mellitus (T2DM) associated non-alcoholic fatty liver disease (NAFLD) is the
fourth-leading cause of death. Hyperglycemia induces various complications, including …

Liver fibrosis has evolved in the past 20 years from a pure laboratory discipline to an area of
great bedside relevance to practicing hepatologists. This evolution reflects growing awarenessnotonlyofthemolecularunderpinn …

Advanced hepatic fibrosis, driven by the activation of hepatic stellate cells (HSCs), affects
millions worldwide and is the strongest predictor of mortality in nonalcoholic steatohepatitis …

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer
cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better …

In 1876, von Kupffer described liver Sternzellen (star-shaped cells). The functions of these
cells remained enigmatic for 75 years until Ito observed lipid-containing perisinusoidal cells …

Substantial evidence now exists to recognize hepatic stellate cells (HSCs) as the main
matrix-producing cells in the process of liver fibrosis. Liver injury of any etiology will …

Background/Aims: Hepatic stellate cells (HSC) are commonly considered the precursor
population of septal myofibroblasts (MF) in cirrhosis. We studied the distribution and …

Hepatic stellate cells (HSCs), a mesenchymal cell type in hepatic parenchyma, have unique
features with respect to their cellular origin, morphology, and function. Normal, quiescent …

Depletion of peroxisome proliferator-activated receptor γ (PPARγ) accompanies
myofibroblastic transdifferentiation of hepatic stellate cells (HSC), the primary cellular event …

Hepatic progenitor cells are immature epithelial cells that reside in the smallest ramifications
of the biliary tree in human liver. These cells are capable of differentiating toward the biliary …