[HTML][HTML] The bidirectional relationship of depression and inflammation: double trouble

E Beurel, M Toups, CB Nemeroff - Neuron, 2020 - cell.com
Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

Immune targets for therapeutic development in depression: towards precision medicine

WC Drevets, GM Wittenberg, ET Bullmore… - Nature reviews Drug …, 2022 - nature.com
Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …

Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)

JJA van Kampen, DAMC van de Vijver… - Nature …, 2021 - nature.com
Key questions in COVID-19 are the duration and determinants of infectious virus shedding.
Here, we report that infectious virus shedding is detected by virus cultures in 23 of the 129 …

The role of inflammation in depression and fatigue

CH Lee, F Giuliani - Frontiers in immunology, 2019 - frontiersin.org
Depression and fatigue are conditions responsible for heavy global societal burden,
especially in patients already suffering from chronic diseases. These symptoms have been …

Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons

C Nagy, M Maitra, A Tanti, M Suderman… - Nature …, 2020 - nature.com
Major depressive disorder (MDD) has an enormous impact on global disease burden,
affecting millions of people worldwide and ranking as a leading cause of disability for almost …

Major depressive disorder

C Otte, SM Gold, BW Penninx, CM Pariante… - Nature reviews Disease …, 2016 - nature.com
Major depressive disorder (MDD) is a debilitating disease that is characterized by
depressed mood, diminished interests, impaired cognitive function and vegetative …

Longitudinal association between depression and inflammatory markers: results from the Netherlands study of depression and anxiety

F Lamers, Y Milaneschi, JH Smit, RA Schoevers… - Biological …, 2019 - Elsevier
Background While cross-sectional associations of inflammatory markers interleukin-6 (IL-6)
and C-reactive protein with major depressive disorder are well established, evidence for …

Genetic contributions of inflammation to depression

J Barnes, V Mondelli, CM Pariante - Neuropsychopharmacology, 2017 - nature.com
This paper describes the effects of immune genes genetic variants and mRNA expression
on depression's risk, severity, and response to antidepressant treatment, through a …

Metabolic and inflammatory markers: associations with individual depressive symptoms

F Lamers, Y Milaneschi, P De Jonge, EJ Giltay… - Psychological …, 2018 - cambridge.org
BackgroundLiterature has shown that obesity, metabolic syndrome and inflammation are
associated with depression, however, evidence suggests that these associations are …

Peripheral biomarkers of major depression and antidepressant treatment response: current knowledge and future outlooks

BS Gadad, MK Jha, A Czysz, JL Furman… - Journal of affective …, 2018 - Elsevier
Background In recent years, we have accomplished a deeper understanding about the
pathophysiology of major depressive disorder (MDD). Nevertheless, this improved …