Emerging data have demonstrated a strong association between the gut microbiota and the
development of cardiovascular disease (CVD) risk factors such as atherosclerosis …

Platelet activation is a complex balance of positive and negative signaling pathways. The
protein kinase C (PKC) family is a major regulator of platelet granule secretion, integrin …

The importance of the second messengers calcium (Ca2+) and diacylglycerol (DAG) in
platelet signal transduction was established more than 30 years ago. Whereas protein …

BACKGROUND: MAGT1 (magnesium transporter 1) is a subunit of the oligosaccharide
protein complex with thiol-disulfide oxidoreductase activity, supporting the process of N …

The coordinated and reciprocal action of serine-threonine protein kinases and protein
phosphatases produces transitory phosphorylation, a fundamental regulatory mechanism for …

Transmembrane signals initiated by a range of extracellular stimuli converge on members of
the Gq family of heterotrimeric G proteins, which relay these signals in target cells. Gq family …

The mechanism by which aspirin consumption is linked to significant reductions in the
incidence of multiple forms of cancer and metastatic spread to distant tissues, resulting in …

Objective—Members of the protein kinase C (PKC) family are shown to positively and
negatively regulate platelet activation. Although positive regulatory roles are extensively …

Diabetic nephropathy (DN) is the main cause of end stage renal disease (ESRD).
Glomerulus damage is one of the primary pathological changes in DN. To reveal the gene …

Members of the protein kinase C (PKC) family of serine/threonine kinases have been
implicated in several physiological processes regulating the activation response of platelets …