Tissues and organs are composed of distinct cell types that must operate in concert to
perform physiological functions. Efforts to create high-dimensional biomarker catalogs of …

Mass spectrometry imaging (MSI) is a powerful tool for label-free mapping of the spatial
distribution of proteins in biological tissues. We have previously demonstrated imaging of …

Imaging of proteoforms in human tissues is hindered by low molecular specificity and limited
proteome coverage. Here, we introduce proteoform imaging mass spectrometry (PiMS) …

Renal biopsies are the gold standard for diagnosis, staging, and prognosis of underlying
parenchymal kidney disease. This article provides an overview of the current indications and …

Head and neck squamous cell carcinomas (HNSCCs) are the seventh most common cancer
and represent a global health burden. Immune checkpoint inhibitors (ICIs) have shown …

Kidney allograft inflammation, mostly attributed to rejection and infection, is an important
cause of graft injury and loss. Standard histopathological assessment of allograft …

Spatially resolved molecular assays provide high dimensional genetic, transcriptomic,
proteomic, and epigenetic information in situ and at various resolutions. Pairing these data …

Improvement of long-term outcomes through targeted treatment is a primary concern in
kidney transplant medicine. Currently, the validation of a rejection diagnosis and …

The kidney functions through the coordination of approximately one million multifunctional
nephrons in 3-dimensional space. Molecular understanding of the kidney has relied on …

Solid organ transplantation (SOT) is the standard of care for end-stage organ disease. The
most frequent complication of SOT involves allograft rejection, which may occur via T cell …