PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)

M He, C Cao, Z Ni, Y Liu, P Song, S Hao, Y He… - … and Targeted Therapy, 2022 - nature.com
Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …

An overview of PROTACs: a promising drug discovery paradigm

Z Liu, M Hu, Y Yang, C Du, H Zhou, C Liu, Y Chen… - Molecular …, 2022 - Springer
Proteolysis targeting chimeras (PROTACs) technology has emerged as a novel therapeutic
paradigm in recent years. PROTACs are heterobifunctional molecules that degrade target …

Deferoxamine B: a natural, excellent and versatile metal chelator

D Bellotti, M Remelli - Molecules, 2021 - mdpi.com
Deferoxamine B is an outstanding molecule which has been widely studied in the past
decade for its ability to bind iron and many other metal ions. The versatility of this metal …

Computational molecular docking and virtual screening revealed promising SARS-CoV-2 drugs

M Hosseini, W Chen, D Xiao… - Precision clinical medicine, 2021 - academic.oup.com
The pandemic of novel coronavirus disease 2019 (COVID-19) has rampaged the world, with
more than 58.4 million confirmed cases and over 1.38 million deaths across the world by 23 …

[HTML][HTML] Antiviral PROTACs: Opportunity borne with challenge

J Liang, Y Wu, K Lan, C Dong, S Wu, S Li, HB Zhou - Cell Insight, 2023 - Elsevier
Proteolysis targeting chimera (PROTAC) degradation of pathogenic proteins by hijacking of
the ubiquitin-proteasome-system has become a promising strategy in drug design. The …

[HTML][HTML] Pyroptotic cell death in SARS-CoV-2 infection: revealing its roles during the immunopathogenesis of COVID-19

M Wang, W Chang, L Zhang… - International Journal of …, 2022 - ncbi.nlm.nih.gov
The rapid dissemination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
the causative agent of coronavirus disease 2019 (COVID-19), remains a global public health …

Direct dual-Z-scheme PANI/Ag2O/Cu2O heterojunction with broad absorption range for photocatalytic degradation of methylene blue

A Guleria, R Sharma, A Singh, NK Upadhyay… - Journal of Water …, 2021 - Elsevier
Abstract The PANI/Ag 2 O/Cu 2 O (PAC) direct dual-Z-scheme heterojunction was
synthesized by ultrasonic-assisted wet impregnation method. The heterojunction utilizes …

On the selectivity of heparan sulfate recognition by SARS-CoV-2 spike glycoprotein

JE Chittum, NV Sankaranarayanan… - ACS Medicinal …, 2021 - ACS Publications
SARS-CoV-2 infects human cells through its surface spike glycoprotein (SgP), which relies
on host cell surface heparan sulfate (HS) proteoglycans that facilitate interaction with the …

[HTML][HTML] Antioxidants and COVID-19

S DE FLORA, R Balansky… - Journal of preventive …, 2021 - ncbi.nlm.nih.gov
Oxidative mechanisms are not only involved in chronic degenerative diseases but also in
infectious diseases, among which viral respiratory diseases. Antioxidants have the capability …

Indomethacin-based PROTACs as pan-coronavirus antiviral agents

J Desantis, B Mercorelli, M Celegato, F Croci… - European Journal of …, 2021 - Elsevier
Abstract Indomethacin (INM), a well-known non-steroidal anti-inflammatory drug, has
recently gained attention for its antiviral activity demonstrated in drug repurposing studies …