The recommendations listed in this guideline are, whenever possible, evidence based. An
initial extensive evidence review, which included literature derived from research involving …

Iron metabolism is a balancing act, and biological systems have evolved exquisite
regulatory mechanisms to maintain iron homeostasis. Iron metabolism disorders are …

The Association for European Cardiovascular Pathology and the Society for Cardiovascular
Pathology have produced this position paper concerning the current role of endomyocardial …

The cardiomyopathies are heart muscle diseases of pri-mary or secondary origin. Primary
cardiomyopathies are often of unknown cause, hence their treatment is limited to general …

The complex pathophysiology in β-thalassemia can translate to multiple morbidities that
affect every organ system. Improved survival due to advances in management means that …

Beta-thalassemia and particularly its transfusion-dependent form (TDT) is a demanding
clinical condition, requiring life-long care and follow-up, ideally in specialized centers and by …

Restrictive cardiomyopathies (RCMs) are a diverse group of myocardial diseases with a
wide range of aetiologies, including familial, genetic and acquired diseases and ranging …

Cardiomyopathies are defined as diseases of the myocardium with associated structural and
functional abnormalities. Knowledge of these pathologies for a long period was not clear in …

Despite the major improvement in therapeutic management of thalassemia major, iron
overload is considered a challenging conundrum in these patients and heart disease still …

RASopathies are a family of developmental disorders that share germline mutations in the
components of the RAS-MAPK pathway leading to dysregulated signalling. A high …