Parkinson disease is characterized by dopaminergic cell loss in the substantia nigra of the
midbrain. There are various imaging markers for Parkinson disease. Recent advances in …

The differential diagnosis of parkinsonian syndromes is considered one of the most
challenging in neurology and error rates in the clinical diagnosis can be high even at …

Aims: The pathophysiological role of iron in Parkinson's disease (PD) was assessed by a
chelation strategy aimed at reducing oxidative damage associated with regional iron …

Purpose To evaluate the sensitivity and specificity of quantitative magnetic resonance (MR)
iron mapping including R2, R2* and magnetic susceptibility to differentiate patients with …

Background Neuroimaging studies help us better understand the pathophysiology and
symptoms of Parkinson's disease (PD). In several of these studies, diffusion tensor imaging …

In Parkinson's disease (PD), iron elevation in specific brain regions as well as selective loss
of dopaminergic neurons is a major pathologic feature. A reliable quantitative measure of …

Objectives: We performed a systematic review to assess alterations in measures of diffusion
tensor imaging (DTI) in parkinsonian syndromes, exploring the potential role of DTI in …

There is a clear need to develop non-invasive markers of substantia nigra progression in
Parkinson's disease. We previously found elevated free-water levels in the substantia nigra …

Conventional single tensor diffusion analysis models have provided mixed findings in the
substantia nigra of Parkinson's disease, but recent work using a bi-tensor analysis model …

Brain iron is tightly regulated by a multitude of proteins to ensure homeostasis. Iron
dyshomeostasis has become a molecular signature associated with aging which is …