3-Mercaptopyruvate sulfurtransferase: An enzyme at the crossroads of sulfane sulfur trafficking

B Pedre, TP Dick - Biological chemistry, 2021 - degruyter.com
Mercaptopyruvate sulfurtransferase (MPST) catalyzes the desulfuration of 3-
mercaptopyruvate to generate an enzyme-bound hydropersulfide. Subsequently, MPST …

[HTML][HTML] Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities

J Bolduc, K Koruza, T Luo, JM Pueyo, TN Vo, D Ezeriņa… - Redox Biology, 2021 - Elsevier
Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein
interactions. Understanding the role of the multiple structural and post-translational …

E2/E3‐independent ubiquitin‐like protein conjugation by Urm1 is directly coupled to cysteine persulfidation

KE Ravichandran, L Kaduhr, B Skupien‐Rabian… - The EMBO …, 2022 - embopress.org
Post‐translational modifications by ubiquitin‐like proteins (UBLs) are essential for nearly all
cellular processes. Ubiquitin‐related modifier 1 (Urm1) is a unique UBL, which plays a key …

[Retracted] Melatonin Attenuates Ischemia/Reperfusion‐Induced Oxidative Stress by Activating Mitochondrial Fusion in Cardiomyocytes

X Ma, S Wang, H Cheng, H Ouyang… - Oxidative Medicine and …, 2022 - Wiley Online Library
Myocardial ischemia/reperfusion (I/R) injury can stimulate mitochondrial reactive oxygen
species production. Optic atrophy 1‐(OPA1‐) induced mitochondrial fusion is an …

Involvement of Urm1, a ubiquitin-like protein, in the regulation of oxidative stress response of toxoplasma gondii

Q Tan, J Wang, J Chen, X Liu, X Chen… - Microbiology …, 2022 - Am Soc Microbiol
ABSTRACT Ubiquitin-related modifier 1 (Urm1) is a ubiquitin-like molecule (UBL) with the
ability to act as a posttranslational protein modifier. Here, we characterized the Toxoplasma …

[HTML][HTML] Structural Insights into the Iodothyronine Deiodinase 2 Catalytic Core and Deiodinase Catalysis and Dimerization

H Towell, D Braun, A Brol, A di Fonzo, E Rijntjes… - Biomolecules, 2024 - mdpi.com
Iodothyronine deiodinases (Dio) are selenocysteine-containing membrane enzymes that
activate and inactivate the thyroid hormones (TH) through reductive iodide eliminations. The …

Molecular basis for thiocarboxylation and release of Urm1 by its E1-activating enzyme Uba4

M Sokołowski, D Kwasna… - Nucleic Acids …, 2024 - academic.oup.com
Abstract Ubiquitin-related modifier 1 (Urm1) is a highly conserved member of the ubiquitin-
like (UBL) family of proteins. Urm1 is a key component of the eukaryotic transfer RNA (tRNA) …

Induced oxidative equilibrium damage and reduced toxin synthesis in Fusarium oxysporum f. sp. niveum by secondary metabolites from Bacillus velezensis WB

K Wang, Z Wang, W Xu - FEMS Microbiology Ecology, 2022 - academic.oup.com
In this study, the antifungal mechanism of secondary metabolites from the WB strain against
Fusarium oxysporum f. sp. niveum (Fon) was investigated. The WB strain induced the …

Urm1: a non-canonical ubl

M Termathe, SA Leidel - Biomolecules, 2021 - mdpi.com
Urm1 (ubiquitin related modifier 1) is a molecular fossil in the class of ubiquitin-like proteins
(UBLs). It encompasses characteristics of classical UBLs, such as ubiquitin or SUMO (small …

Encystation and Stress Responses under the Control of Ubiquitin-like Proteins in Pathogenic Amoebae

A Samba-Louaka, E Labruyère, M Matondo… - Microorganisms, 2023 - mdpi.com
Amoebae found in aquatic and terrestrial environments encompass various pathogenic
species, including the parasite Entamoeba histolytica and the free-living Acanthamoeba …