Synthetic polymer based Polyfectins (cationic polymer-DNA complex) have received
intensive scientific research as they can potentially circumvent problems associated with …

Cell penetrating peptides, generally categorized as amphipathic or cationic depending on
their sequence, are increasingly drawing attention as a non-invasive delivery technology for …

Polymeric gene delivery vectors show great potential for the construction of the ideal gene
delivery system. These systems harness their ability to incorporate versatile functional traits …

Peptides as functional biomaterials offer the possibility of incorporating various biological
activities required for different biomedical applications. Here, we take advantage of this …

Nucleic acids are not only expected to assume a pivotal position as “drugs” in the treatment
of genetic and acquired diseases, but could also act as molecular cues to control the …

Vascular endothelial growth factor (VEGF) is a multifunctional angiogenic growth factor that
is a primary stimulant of the development and maintenance of a vascular network in the …

Cell delivery reagents often exploit the endocytic pathway as a route of cell entry. Once
endocytosed, these reagents must overcome endosomal entrapment to ensure the release …

Gene therapy aimed at the respiratory epithelium holds therapeutic potential for diseases
such as cystic fibrosis and lung cancer. Polyethylenimine (PEI) has been utilized for gene …

Reducible polycations represent promising carriers of therapeutic nucleic acids. Oligomers
of 2-dimethylaminoethyl methacrylate (DMAEMA) containing terminal thiol groups were …

RNA therapeutics (eg siRNA, oligonucleotides, mRNA, etc.) show great potential for the
treatment of a myriad of diseases. However, to reach their site of action in the cytosol or …