Impact of hypoxia on male reproductive functions

PA Oyedokun, RE Akhigbe, LO Ajayi… - Molecular and Cellular …, 2023 - Springer
Male reproductive functions, which include testicular steroidogenesis, spermatogenesis, and
sexual/erectile functions are key in male fertility, but may be adversely altered by several …

Viral infections and male infertility: a comprehensive review of the role of oxidative stress

RE Akhigbe, S Dutta, MA Hamed, AF Ajayi… - … in Reproductive Health, 2022 - frontiersin.org
Viral infections have been a part of human existence to date, though viruses have posed a
huge threat with various outbreaks lately. These threats are associated with reproductive …

Zinc improves sexual and erectile function in HAART-treated rats via the upregulation of erectogenic enzymes and maintenance of redox balance

RE Akhigbe, MA Hamed, AF Odetayo, TM Akhigbe… - The Aging …, 2023 - Taylor & Francis
Purpose HAART has been shown to impair sexual function and penile erection via
perturbation of penile redox balance, while zinc has been established to exert antioxidant …

[HTML][HTML] Glutamine prevents upregulation of NF-kB signaling and caspase 3 activation in ischaemia/reperfusion-induced testicular damage: An animal model

OA Afolabi, DC Anyogu, MA Hamed, AF Odetayo… - Biomedicine & …, 2022 - Elsevier
Aim Testicular ischaemia/reperfusion (I/R) injury is a major consequence of testicular torsion
with possible attendant risk of male infertility. Glutamine, on the other hand, is a known …

[HTML][HTML] Glutamine restores testicular glutathione-dependent antioxidant defense and upregulates NO/cGMP signaling in sleep deprivation-induced reproductive …

MA Hamed, TM Akhigbe, RE Akhigbe… - Biomedicine & …, 2022 - Elsevier
Oxidative stress has been linked with sleep deprivation (SD)-induced pathological
conditions and reproductive dysfunction. On the other hand, glutamine has been established …

Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats

EE Besong, TM Akhigbe, PJ Ashonibare… - Redox …, 2023 - Taylor & Francis
Aim: The present study evaluated the effect of lead exposure with and without zinc therapy
on male sexual and erectile function. Methods: Twenty male Wistar rats were randomly …

Zinc normalizes hepatic lipid handling via modulation of ADA/XO/UA pathway and caspase 3 signaling in highly active antiretroviral therapy-treated Wistar rats

MA Hamed, RE Akhigbe, AO Aremu… - Chemico-Biological …, 2022 - Elsevier
Background Although highly active antiretroviral therapy (HAART) is effective in the
management of HIV, it has been reported to induce hepatic injury and non-alcoholic fatty …

Overview of the Effects of Moringa oleifera Leaf Extract on Oxidative Stress and Male Infertility: A Review

K Mohlala, U Offor, E Monageng, NB Takalani… - Applied Sciences, 2023 - mdpi.com
According to a recent report by the WHO, 50–80 million people suffer with infertility. Amongst
these populations, male counterparts account for 20–50% of infertility cases. The aetiology …

Acetate Abates Arsenic-Induced Male Reproductive Toxicity by Suppressing HDAC and Uric Acid–Driven Oxido-inflammatory NFkB/iNOS/NO Response in Rats

EE Besong, TM Akhigbe, JN Obimma… - … Trace Element Research, 2024 - Springer
Arsenic is associated with male reproductive toxicity through histone deacetylation and
oxido-inflammatory injury. Notwithstanding, short-chain fatty acids such as acetate exert anti …

Gut microbiota-gonadal axis: the impact of gut microbiota on reproductive functions

VJ Ashonibare, BA Akorede, PJ Ashonibare… - Frontiers in …, 2024 - frontiersin.org
The influence of gut microbiota on physiological processes is rapidly gaining attention
globally. Despite being under-studied, there are available data demonstrating a gut …