Animal models of Parkinson's disease: a guide to selecting the optimal model for your research

J Lama, Y Buhidma, EJR Fletcher, S Duty - Neuronal Signaling, 2021 - portlandpress.com
Parkinson's disease (PD) is a complex, multisystem disorder characterised by α-synuclein
(SNCA) pathology, degeneration of nigrostriatal dopaminergic neurons, multifactorial …

Neuroprotective Effects of Nano-Curcumin against Cypermethrin Associated Oxidative Stress and Up-Regulation of Apoptotic and Inflammatory Gene Expression in …

M Ashafaq, S Hussain, S Alshahrani, R Siddiqui… - Antioxidants, 2023 - mdpi.com
Cypermethrin (CPM) is the most toxic synthetic pyrethroid that has established neurotoxicity
through oxidative stress and neurochemical agitation in experimental rats. The toxic effects …

A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome

SE Hurst, E Liktor-Busa, A Moutal, S Parker… - Neuronal …, 2018 - portlandpress.com
We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …

Permethrin exposure primes neuroinflammatory stress response to drive depression-like behavior through microglial activation in a mouse model of Gulf War Illness

SX Naughton, EJ Yang, U Iqbal, K Trageser… - Journal of …, 2024 - Springer
Abstract Gulf War Illness (GWI) is a chronic multisymptom disorder that affects approximately
25–32% of Gulf War veterans and is characterized by a number of symptoms such as …

Exposure to sub-lethal doses of permethrin is associated with neurotoxicity: Changes in bioenergetics, redox markers, neuroinflammation and morphology

TG López-Aceves, E Coballase-Urrutia, F Estrada-Rojo… - Toxics, 2021 - mdpi.com
Permethrin (PERM) is a member of the class I family of synthetic pyrethroids. Human use
has shown that it affects different systems, with wide health dysfunctions. Our aim was to …

[HTML][HTML] 驱避剂安全性研究进展

张婉莉, 彭恒, 单文琪, 马雅军 - 中国媒介生物学及控制杂志, 2022 - html.rhhz.net
驱避剂通过影响嗅觉系统对吸血昆虫产生驱避作用, 减少叮咬, 从而预防虫媒病的发生.
驱避剂在推荐剂量下使用应是安全的. 然而随着长期观察数据的累积, 驱避剂引起的毒性案例 …

Introduction: Back to the Future‐Solutions for Parasitic Problems

R Şimşek, A Farooqui, SUD Khan… - … Immune Responses and …, 2023 - Wiley Online Library
The organisms that cause the greatest harm to humanity are parasites. Since long ago,
parasites have been viewed as a scourge that should be eradicated. Although the …

Permethrin inhibits tube formation and viability of endothelial cells

HS Lee, HJ Song, Y Park… - Journal of the Science …, 2022 - Wiley Online Library
BACKGROUND Exposure to environmental chemicals has been linked with endothelial
dysfunction, which is a leading cause of human diseases, including atherosclerosis …

Sex-Specific Cypermethrin Induced Hippocampal Neurotoxicity Is Via the Modulation of Signaling Molecules for Antioxidant Defense, Membrane Integrity, Apoptosis …

A Imam, M Busari, C Oyegbola, BF Moyinoluwa… - 2024 - researchsquare.com
Pesticides, despite their intended use against pests, can have detrimental effects on non-
target organisms, including humans. Its main route of exposure in urban areas is through …

Mitochondrial bioenergetics and redox dysfunction in nephrotoxicity induced by pyrethroid permethrin are ameliorated by flavonoid-rich fraction

N Aoiadni, H Jdidi, AE Feki, H Fetoui… - … Science and Pollution …, 2022 - Springer
The present study was designed to evaluate in vitro and in vivo the potential anti-
inflammatory and nephroprotective potential of ethyl acetate fraction extracted from Fumaria …