Betanodavirus and VER disease: a 30-year research review

I Bandín, S Souto - Pathogens, 2020 - mdpi.com
The outbreaks of viral encephalopathy and retinopathy (VER), caused by nervous necrosis
virus (NNV), represent one of the main infectious threats for marine aquaculture worldwide …

[HTML][HTML] Understanding the interaction between Betanodavirus and its host for the development of prophylactic measures for viral encephalopathy and retinopathy

JZ Costa, KD Thompson - Fish & Shellfish Immunology, 2016 - Elsevier
Over the last three decades, the causative agent of viral encephalopathy and retinopathy
(VER) disease has become a serious problem of marine finfish aquaculture, and more …

Development and characterization of monoclonal antibodies against red-spotted grouper nervous necrosis virus and their neutralizing potency in vitro

Z Zhang, J Xing, X Tang, X Sheng, H Chi, W Zhan - Aquaculture, 2022 - Elsevier
Nervous necrosis virus (NNV) has caused severe diseases in global aquaculture industry
with tremendous economic and environmental damages. While red-spotted grouper NNV …

Identification of a novel linear B-cell epitope on the nucleocapsid protein of porcine deltacoronavirus

J Fu, R Chen, J Hu, H Qu, Y Zhao, S Cao… - International journal of …, 2020 - mdpi.com
Porcine deltacoronavirus (PDCoV), first identified in 2012, is a swine enteropathogen now
found in many countries. The nucleocapsid (N) protein, a core component of PDCoV, is …

Identification of b-cell epitopes on capsid protein reveals two potential neutralization mechanisms in red-spotted grouper nervous necrosis virus

Z Zhang, J Xing, X Tang, X Sheng, H Chi… - Journal of …, 2023 - Am Soc Microbiol
Nervous necrosis virus (NNV), a formidable pathogen in marine and freshwater fish, has
inflicted enormous financial tolls on the aquaculture industry worldwide. Although capsid …

In vitro neutralization of nervous necrosis virus by a nanobody binding to the protrusion domain of capsid protein

S Zhu, B Miao, YZ Zhang, WW Zeng, DS Wang, SQ Su - Aquaculture, 2022 - Elsevier
Viral encephalopathy and retinopathy (VER), caused by nervous necrosis virus (NNV), has
infected more than 177 marine and freshwater species belonging to 30 families, posing a …

Nervous necrosis virus coat protein mediates host translation shutoff through nuclear translocalization and degradation of polyadenylate binding protein

CA Cheng, JM Luo, MH Chiang, KY Fang… - Journal of …, 2021 - Am Soc Microbiol
Nervous necrosis virus (NNV) belongs to the Betanodavirus genus of the Nodaviridae family
and is the main cause of viral nervous necrosis disease in marine fish larvae and juveniles …

Peptide scanning-assisted identification of a monoclonal antibody-recognized linear B-cell epitope

CW Chen, CY Chang - Journal of Visualized Experiments …, 2017 - pmc.ncbi.nlm.nih.gov
The identification of an antigenic epitope by the immune system allows for the
understanding of the protective mechanism of neutralizing antibodies that may facilitate the …

Elucidating the Functional Roles of Helper and Cytotoxic T Cells in the Cell-Mediated Immune Responses of Olive Flounder (Paralichthys olivaceus)

JW Jung, AR Lee, J Kim, YR Kim, JMS Lazarte… - International Journal of …, 2021 - mdpi.com
In higher vertebrates, helper and cytotoxic T cells, referred to as CD4 and CD8 T
lymphocytes, respectively, are mainly associated with adaptive immunity. The adaptive …

Immune and protective effects of subunit vaccines from S-domain or P-domain in capsid protein against nervous necrosis virus in pearl gentian grouper

T Lin, J Xing, X Tang, X Sheng, H Chi, W Zhan - Aquaculture, 2023 - Elsevier
Capsid protein (CP), only structural protein of nervous necrosis virus (NNV), is a major target
for viral encephalopathy and retinopathy (VER) prevention and virus detection. It is also …