Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …

The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …

Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

Background DNA methylation is an epigenetic chromatin mark that allows heterochromatin
formation and gene silencing. It has a fundamental role in preserving genome stability …

From a biological point of view, aging can be considered a progressive inability of an
organism to react to stress, maintain homeostasis, and survive unfavourable changes during …

Given the dramatic increase in ageing populations, it is of great importance to understand
the genetic and molecular determinants of healthy ageing and longevity. Semi …

The ability to estimate the age of the donor from recovered biological material at a crime
scene can be of substantial value in forensic investigations. Aging can be complex and is …

Aging is characterized by the progressive decline of biochemical and physiological function
in an individual. Consequently, aging is a major risk factor for diseases like cancer, obesity …

Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …

Human aging is currently defined as a physiological decline of biological functions in the
body with a continual adaptation to internal and external damaging. The endocrine system …