Emerging rules for subunit-based, multiantigenic, multistage chemically synthesized vaccines

ME Patarroyo, MA Patarroyo - Accounts of chemical research, 2008 - ACS Publications
Seventeen million people die of transmittable diseases and 2/3 of the world's population
suffer them annually. Malaria, tuberculosis, AIDS, hepatitis, and reemerging and new …

H7N9 T-cell epitopes that mimic human sequences are less immunogenic and may induce Treg-mediated tolerance

R Liu, L Moise, R Tassone, AH Gutierrez… - Human vaccines & …, 2015 - Taylor & Francis
Avian-origin H7N9 influenza is a novel influenza A virus (IAV) that emerged in humans in
China in 2013. Using immunoinformatics tools, we identified several H7N9 T cell epitopes …

[HTML][HTML] Immune protection-inducing protein structures (IMPIPS) against malaria: the weapons needed for beating Odysseus

ME Patarroyo, MA Patarroyo, L Pabón, H Curtidor… - Vaccine, 2015 - Elsevier
The review covers the functional and structural approach followed by our group for more
than 34 years in the search for a methodology that allows the rational design of chemically …

Functional, immunological and three-dimensional analysis of chemically synthesised sporozoite peptides as components of a fully-effective antimalarial vaccine

H Curtidor, M Vanegas, MP Alba… - Current medicinal …, 2011 - ingentaconnect.com
Our ongoing search for a fully-effective vaccine against the Plasmodium falciparum parasite
(causing the most lethal form of human malaria) has been focused on identifying and …

Malaria parasite survival depends on conserved binding peptides' critical biological functions

ME Patarroyo, G Arévalo-Pinzón, C Reyes… - Current issues in …, 2016 - mdpi.com
Biochemical, structural and single amino acid level analysis of 49 Plasmodium falciparum
protein regions (13 sporozoite and 36 merozoite proteins) has highlighted the functional role …

Quantum chemical analysis of MHC-peptide interactions for vaccine design

WA Agudelo, ME Patarroyo - Mini Reviews in Medicinal …, 2010 - ingentaconnect.com
The development of an adequate immune response against pathogens is mediated by
molecular interactions between different cell types. Among them, binding of antigenic …

Towards the development of a fully protective Plasmodium falciparum antimalarial vaccine

ME Patarroyo, A Bermudez… - Expert Review of …, 2012 - Taylor & Francis
If ever there were a truism then it would be that a completely protective Plasmodium
falciparum malaria vaccine is desperately needed. Our institute has devoted all its efforts …

Atomic evidence that modification of H-bonds established with amino acids critical for host-cell binding induces sterile immunity against malaria

ME Patarroyo, G Cifuentes, C Piraján… - Biochemical and …, 2010 - Elsevier
Based on the 3D X-ray crystallographic structures of relevant proteins of the malaria parasite
involved in invasion to host cells and 3D NMR structures of High Activity Binding Peptides …

Comparative molecular and three-dimensional analysis of the peptide–MHC II binding region in both human and Aotus MHC-DRB molecules confirms their …

ME Patarroyo, G Cifuentes, J Baquero - Immunogenetics, 2006 - Springer
A vaccine against malaria is desperately needed, and Aotus monkeys are highly susceptible
to experimental infection with malarial parasites. A thorough analysis of this monkey's …

[HTML][HTML] A rational strategy for a malarial vaccine development

JM Lozano, ME Patarroyo - Microbes and infection, 2007 - Elsevier
Twenty years ago we reported the first synthetic peptide-based anti-malarial vaccine named
SPf66, which conferred limited protective efficacy in large-scale human field-trials. Our …