Non‐alcoholic fatty liver disease (NAFLD) is a continuous spectrum of diseases
characterized by excessive lipid accumulation in hepatocytes. NAFLD progresses from …

The genetic alterations in cancer cells are tightly linked to signaling pathway dysregulation.
Ras is a key molecule that controls several tumorigenesis-related processes, and mutations …

Nonalcoholic fatty liver disease (NAFLD)–induced hepatocellular carcinoma (HCC) is an
emerging malignancy in the developed world; however, mechanisms that contribute to its …

Most cells in the liver are polyploid, but the functional role of polyploidy is unknown.
Polyploidization occurs through cytokinesis failure and endoreduplication around the time of …

Background & Aims O-GlcNAc transferase (OGT) is a unique glycosyltransferase involved in
metabolic reprogramming. We investigated the functional role of OGT in non-alcoholic fatty …

Health authorities are alarmed worldwide about the increase of obesity and overweight in
the last decades which lead to adverse health effects including inflammation, cancer …

Obesity is the most common nutritional disease in dogs, and its prevalence has increased in
recent decades. Several countries have demonstrated a prevalence of obesity in dogs …

Nonalcoholic fatty liver disease (NAFLD) has recently been recognized as an important
etiology contributing to the increased incidence of hepatocellular carcinoma (HCC). NAFLD …

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths in
men, and the sixth in women. Non-alcoholic fatty liver disease (NAFLD) is now one of the …

Obesity, defined as a state of positive energy balance with a body mass index exceeding 30
kg/m2 in adults and 95th percentile in children, is an increasing global concern …