Fucose is a 6-deoxy hexose in the l-configuration found in a large variety of different
organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by …

Members of the CCN family of matricellular proteins are crucial for embryonic development
and have important roles in inflammation, wound healing and injury repair in adulthood …

The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …

The identification of multipotential mesenchymal stem cells (MSCs) derived from adult
human tissues, including bone marrow stroma and a number of connective tissues, has …

Coordinated production and remodeling of the extracellular matrix is essential during
development. It is of particular importance for skeletogenesis, as the ability of cartilage and …

Context Although little is known as yet about the processes that coordinate cell-signalling
pathways, matrix proteins are probably major players in this type of global control. The CCN …

Members of the CCN (CYR61/CTGF/NOV) family have emerged as dynamically expressed,
extracellular matrix-associated proteins that play critical roles in cardiovascular and skeletal …

The CCN family is a group of six secreted proteins that specifically associate with the
extracellular matrix. Structurally, CCN proteins are modular, containing up to four distinct …

The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …

The long bones of the vertebrate appendicular skeleton arise from initially continuous
condensations of mesenchymal cells that subsequently segment and cavitate to form …