Mitochondrial unfolded protein response (mitoUPR) is a mitochondria stress response to
maintain mitochondrial proteostasis during stress. Increasing evidence suggests that …

The mitochondrial unfolded protein response (UPRmt) is a molecular mechanism that
maintains mitochondrial proteostasis under stress and is closely related to various metabolic …

High-fat-diet (HFD) feeding is associated with liver oxidative stress (OS), n-3 long-chain
polyunsaturated fatty acid (n-3 LCPUFA) depletion, hepatic steatosis and mitochondrial …

Background The muscle decline due to aging, called sarcopenia and functional
compromise, are common occurrences in patients with chronic heart failure (CHF). Intestinal …

Caseinolytic peptidase P (ClpP) is a mammalian quality control protease that is proposed to
play an important role in the initiation of the mitochondrial unfolded protein response (UPR …

Purpose Sarcopenia or age-related muscle loss is a common finding in patients with chronic
obstructive pulmonary disease (COPD) and may lead to functional compromise. The …

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to improve insulin
sensitivity and glucose homeostasis in animal models of insulin resistance, but the involved …

Background & Aims Mitochondrial dysfunction is considered a pathogenic linker in the
development of non-alcoholic steatohepatitis (NASH). Inappropriate mitochondrial protein …

Muscle disuse in the hindlimb unloaded (HU) mice causes significant atrophy and
weakness. However, the cellular and molecular mechanisms driving disuse-muscle atrophy …

ONC201 is a well-known caseinolytic protease (ClpP) activator with established benefits
against multiple tumors, including colorectal cancer (CRC). In this study, we investigated the …