Neurodevelopmental disorders: from genetics to functional pathways
I Parenti, LG Rabaneda, H Schoen, G Novarino - Trends in Neurosciences, 2020 - cell.com
Neurodevelopmental disorders (NDDs) are a class of disorders affecting brain development
and function and are characterized by wide genetic and clinical variability. In this review, we …
and function and are characterized by wide genetic and clinical variability. In this review, we …
Genetic and epigenetic etiology underlying autism spectrum disorder
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized
by difficulties in social interaction, language development delays, repeated body …
by difficulties in social interaction, language development delays, repeated body …
mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity
Postmortem studies have revealed increased density of excitatory synapses in the brains of
individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR …
individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR …
Infraslow state fluctuations govern spontaneous fMRI network dynamics
Spontaneous brain activity as assessed with resting-state fMRI exhibits rich spatiotemporal
structure. However, the principles by which brain-wide patterns of spontaneous fMRI activity …
structure. However, the principles by which brain-wide patterns of spontaneous fMRI activity …
[HTML][HTML] CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories
CE Villa, C Cheroni, CP Dotter, A López-Tóbon… - Cell Reports, 2022 - cell.com
Mutations in the chromodomain helicase DNA-binding 8 (CHD8) gene are a frequent cause
of autism spectrum disorder (ASD). While its phenotypic spectrum often encompasses …
of autism spectrum disorder (ASD). While its phenotypic spectrum often encompasses …
The emerging role of chromatin remodelers in neurodevelopmental disorders: a developmental perspective
B Mossink, M Negwer, D Schubert… - Cellular and Molecular …, 2021 - Springer
Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …
Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes
Abstract Autism Spectrum Disorder (ASD) is characterized by substantial, yet highly
heterogeneous abnormalities in functional brain connectivity. However, the origin and …
heterogeneous abnormalities in functional brain connectivity. However, the origin and …
Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice
Autism spectrum disorders (ASDs) are four times more common in males than in females,
but the underlying mechanisms are poorly understood. We characterized sexually dimorphic …
but the underlying mechanisms are poorly understood. We characterized sexually dimorphic …
Gene–environment interactions in developmental neurotoxicity: a case study of synergy between chlorpyrifos and CHD8 knockout in human brainspheres
S Modafferi, X Zhong, A Kleensang… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: Autism spectrum disorder (ASD) is a major public health concern caused by
complex genetic and environmental components. Mechanisms of gene–environment (G× E) …
complex genetic and environmental components. Mechanisms of gene–environment (G× E) …
Network structure of the mouse brain connectome with voxel resolution
Fine-grained descriptions of brain connectivity are required to understand how neural
information is processed and relayed across spatial scales. Previous investigations of the …
information is processed and relayed across spatial scales. Previous investigations of the …