Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide.
However, due to its wide availability, it is frequently implicated in intentional or unintentional …

Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress.
However, its source, pathophysiological role and possible therapeutic potential if targeted …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Acute and acute-on-chronic liver failure (ALF and ACLF), though distinct clinical entities, are
considered syndromes of innate immune dysfunction. Patients with ALF and ACLF display …

Drug-induced acute liver failure carries a high morbidity and mortality rate. Acetaminophen
overdose is the number one cause of acute liver failure and remains a major problem in …

Hepatotoxicity is a serious problem during drug development and for the use of many
established drugs. For example, acetaminophen overdose is currently the most frequent …

Although considered safe at therapeutic doses, at higher doses, acetaminophen produces a
centrilobular hepatic necrosis that can be fatal. Acetaminophen poisoning accounts for …

Kupffer cells (KC) constitute 80–90% of the tissue macrophages present in the body. They
reside within the lumen of the liver sinusoids, and are therefore constantly exposed to gut …

Acetaminophen (APAP) hepatotoxicity because of overdose is the most frequent cause of
acute liver failure in the western world. Metabolic activation of APAP and protein adduct …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US,
and decades of intense study of its pathogenesis resulted in the development of the antidote …