Present knowledge on peroxiredoxins is reviewed with special emphasis on catalytic
principles, specificities and biological function. Peroxiredoxins are low efficiency …

The Arabidopsis genome contains nine open reading frames with homology to members of
the peroxiredoxin (prx) family: one 1‐Cys‐prx, two 2‐Cys‐prx, five type II‐prx, and one …

The relative amounts of ovothiol A (N1-methyl-4-mercaptohistidine) and trypanothione [N1,
N8-bis (glutathionyl) spermidine] have been determined in all life cycle stages of …

The presence of thiols in living systems is critical for the maintenance of cellular redox
potentials and protein thiol-disulfide ratios, as well as for the protection of cells from reactive …

Neglected diseases are a major global cause of illness, long-term disability and death.
Chagas' disease is a parasitic infection widely distributed throughout Latin America, with …

The bis (glutathionyl) spermidine trypanothione exclusively occurs in parasitic protozoa of
the order Kinetoplastida, such as trypanosomes and leishmania, some of which are the …

Trypanosoma cruziglutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid,
phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which …

Tryparedoxin peroxidase (TXNPx) of Trypanosomatidae is the terminal peroxidase of a
complex redox cascade that detoxifies hydroperoxides by NADPH (Nogoceke et al., Biol …

Trypanosomatids are the causative agents of African sleeping sickness, Chagas' disease
and the three forms of leihmaniasis. New drugs against these parasitic protozoa are urgently …

Protozoa of the order Kinetoplastida differ from other organisms in their ability to conjugate
glutathione (l-γ-glutamyl-cysteinyl-glycine) and spermidine to form trypanothione [N 1, N 8 …