Deciphering the Warburg effect: metabolic reprogramming, epigenetic remodeling, and cell dedifferentiation
A century ago, Otto Heinrich Warburg made a seminal discovery now known as the Warburg
effect. This metabolic signature, prevalent across all cancer cells, is characterized by the …
effect. This metabolic signature, prevalent across all cancer cells, is characterized by the …
Blocking the WNT/β-catenin pathway in cancer treatment: pharmacological targets and drug therapeutic potential
X Zhao, Y Ma, J Luo, K Xu, P Tian, C Lu, J Song - Heliyon, 2024 - cell.com
The WNT/β-catenin signaling pathway plays crucial roles in tumorigenesis and relapse,
metastasis, drug resistance, and tumor stemness maintenance. In most tumors, the WNT/β …
metastasis, drug resistance, and tumor stemness maintenance. In most tumors, the WNT/β …
Inhibition of mucus secretion by niclosamide and benzbromarone in airways and intestine
J Ousingsawat, R Centeio, N Reyne, A McCarron… - Scientific Reports, 2024 - nature.com
Abstract The Ca2+ activated Cl− channel TMEM16A (anoctamin 1; ANO1) is expressed in
secretory epithelial cells of airways and intestine. Previous studies provided evidence for a …
secretory epithelial cells of airways and intestine. Previous studies provided evidence for a …
Induction of oxidative stress and ferroptosis in triple-negative breast cancer cells by niclosamide via blockade of the function and expression of SLC38A5 and …
M Mathew, S Sivaprakasam… - Antioxidants, 2024 - mdpi.com
The amino acid transporters SLC38A5 and SLC7A11 are upregulated in triple-negative
breast cancer (TNBC). SLC38A5 transports glutamine, methionine, glycine and serine, and …
breast cancer (TNBC). SLC38A5 transports glutamine, methionine, glycine and serine, and …
Slack K+ channels confer protection against myocardial ischaemia/reperfusion injury
Abstract Aims Na+-activated Slack potassium (K+) channels are increasingly recognized as
regulators of neuronal activity, yet little is known about their role in the cardiovascular …
regulators of neuronal activity, yet little is known about their role in the cardiovascular …
[HTML][HTML] Optimizing Niclosamide for Cancer Therapy: Improving Bioavailability via Structural Modification and Nanotechnology
R Wiggins, J Woo, S Mito - Cancers, 2024 - mdpi.com
Inhibition of multiple cancer-related pathways has made niclosamide a promising candidate
for the treatment of various cancers. However, its clinical application has been significantly …
for the treatment of various cancers. However, its clinical application has been significantly …
Targeting the epithelial–mesenchymal transition (EMT) pathway with combination of Wnt inhibitor and chalcone complexes in lung cancer cells
Non‐small cell lung cancer (NSCLC) is the most common type of the lung cancer. Despite
development in treatment options in NSCLC, the overall survival ratios is still poor due to …
development in treatment options in NSCLC, the overall survival ratios is still poor due to …
The Warburg effect drives dedifferentiation through epigenetic reprogramming
H Jiang, M Jedoui, J Ye - Cancer Biology & Medicine, 2024 - pmc.ncbi.nlm.nih.gov
German biochemist and cell physiologist, Otto H. Warburg (Figure 1), made a
groundbreaking discovery in 1923. Specifically, tumors were shown to consume large …
groundbreaking discovery in 1923. Specifically, tumors were shown to consume large …
High G9a Expression in DLBCL and Its Inhibition by Niclosamide to Induce Autophagy as a Therapeutic Approach
CM Hsu, KC Chang, TM Chuang, ML Chu, PW Lin… - Cancers, 2023 - mdpi.com
Simple Summary Diffuse large B-cell lymphoma (DLBCL) is a prevalent hematological
malignancy which is characterized by rapid cancer cell growth and aggressive progression …
malignancy which is characterized by rapid cancer cell growth and aggressive progression …
Polyanhydride Copolymer-Based Niclosamide Nanoparticles for Inhibiting Triple-Negative Breast Cancer: Metabolic Responses and Synergism with Paclitaxel
SK Nethi, S Kothadiya, BM White… - … Applied Materials & …, 2024 - ACS Publications
The heterogeneity of tumors and the lack of effective therapies have resulted in triple-
negative breast cancer (TNBC) exhibiting the least favorable outcomes among breast …
negative breast cancer (TNBC) exhibiting the least favorable outcomes among breast …