Ferroptosis is a recently recognized cell death modality that is morphologically,
biochemically and genetically distinct from other forms of cell death and that has emerged to …

Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Metabolic reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC).
Here we investigated metabolic dependencies in a panel of ccRCC cell lines using nutrient …

Renal cell carcinoma (RCC) is one of the most common tumours of the urinary system, and
is insidious and not susceptible to chemoradiotherapy. As the most common subtype of RCC …

Recent studies have established that tumors can reprogram the pathways involved in
nutrient uptake and metabolism to withstand the altered biosynthetic, bioenergetics and …

Increasing evidence from epidemiological, preclinical and clinical studies suggests that
dysregulated inflammatory response plays a pivotal role in a multitude of chronic ailments …

Evidence has emerged in the last two decades that at the molecular level most chronic
diseases, including cancer, are caused by a dysregulated inflammatory response. The …

The tissue composition of polyunsaturated fatty acids is important to health and depends on
both dietary intake and metabolism controlled by genetic polymorphisms that should be …

Extensive research within the last half a century has revealed that cancer is caused by
dysregulation of as many as 500 different gene products. Most natural products target …

Pulmonary fibrosis is a pathologic process associated with scarring of the lung interstitium.
Interstitial lung diseases (ILDs) encompass a large and heterogenous group of disorders, a …