Many regeneration contexts require the presence of regenerating nerves as a transient
component of the progenitor cell niche. Here we review nerve involvement in regeneration …

Salamander limb regeneration is a classical model of tissue morphogenesis and patterning.
Through recent advances in cell labeling and molecular analysis, a more precise …

Biologic scaffolds composed of extracellular matrix (ECM) are commonly used repair
devices in preclinical and clinical settings; however the use of these scaffolds for peripheral …

While considerable progress has been made towards understanding the complex processes
and pathways that regulate human wound healing, regenerative medicine has been unable …

Chitin, a biopolymer of N-acetylglucosamine, is abundant in invertebrates and fungi and is
an important structural molecule [1, 2]. There has been a longstanding belief that vertebrates …

Limb regeneration is observed in certain members of the animal phyla. Some animals keep
this ability during their entire life while others lose it at some time during development. How …

Understanding how the limb blastema is established after the initial wound healing
response is an important aspect of regeneration research. Here we performed parallel …

The experimental study of amphibian limb regeneration spans most of the 20th century and
the first decade of the 21st century. We first review the major questions investigated over this …

Zebrafish faithfully regenerate their caudal fin after amputation. During this process, both
differentiated cells and resident progenitors migrate to the wound site and undergo lineage …

The mechanisms that regulate growth and size of the regenerating limb in tetrapods such as
the Mexican axolotl are unknown. Upon the completion of the developmental stages of …